%0 Journal Article
%A Jiang, Yixin
%A Spurny, Manuela
%A Schübel, Ruth
%A Nonnenmacher, Tobias
%A Schlett, Christopher L
%A von Stackelberg, Oyunbileg
%A Ulrich, Cornelia M
%A Kaaks, Rudolf
%A Kauczor, Hans-Ulrich
%A Kühn, Tilman
%A Nattenmüller, Johanna
%T Changes in Pancreatic Fat Content Following Diet-Induced Weight Loss.
%J Nutrients
%V 11
%N 4
%@ 2072-6643
%C Basel
%I MDPI
%M DKFZ-2019-01308
%P 912
%D 2019
%X Obesity can lead to ectopic pancreatic fat accumulation and increase the risk for type 2 diabetes. Smaller intervention trials have shown a decrease in pancreatic fat content (PFC) with weight loss, and we intended to investigate the effects of weight loss on PFC in a larger trial.Data from the HELENA-Trial, a randomized controlled trial (RCT) among 137 non-diabetic obese adults were used. The study cohort was classified into 4 quartiles based on weight change between baseline and 12 weeks post-intervention. Changes in PFC (baseline, 12 weeks and 50 weeks post-intervention) upon weight loss were analyzed by linear mixed models. Spearman's coefficients were used to obtain correlations between anthropometric parameters, blood biochemical markers, and PFC.At baseline, PFC only showed a significant correlation with visceral adipose tissue (VAT) (r = 0.41). Relative changes in PFC were significantly (p = 0.01) greater in Q4 (-30.8 ± 5.7
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:31018616
%R 10.3390/nu11040912
%U https://inrepo02.dkfz.de/record/143739