TY  - JOUR
AU  - Jiang, Yixin
AU  - Spurny, Manuela
AU  - Schübel, Ruth
AU  - Nonnenmacher, Tobias
AU  - Schlett, Christopher L
AU  - von Stackelberg, Oyunbileg
AU  - Ulrich, Cornelia M
AU  - Kaaks, Rudolf
AU  - Kauczor, Hans-Ulrich
AU  - Kühn, Tilman
AU  - Nattenmüller, Johanna
TI  - Changes in Pancreatic Fat Content Following Diet-Induced Weight Loss.
JO  - Nutrients
VL  - 11
IS  - 4
SN  - 2072-6643
CY  - Basel
PB  - MDPI
M1  - DKFZ-2019-01308
SP  - 912
PY  - 2019
AB  - Obesity can lead to ectopic pancreatic fat accumulation and increase the risk for type 2 diabetes. Smaller intervention trials have shown a decrease in pancreatic fat content (PFC) with weight loss, and we intended to investigate the effects of weight loss on PFC in a larger trial.Data from the HELENA-Trial, a randomized controlled trial (RCT) among 137 non-diabetic obese adults were used. The study cohort was classified into 4 quartiles based on weight change between baseline and 12 weeks post-intervention. Changes in PFC (baseline, 12 weeks and 50 weeks post-intervention) upon weight loss were analyzed by linear mixed models. Spearman's coefficients were used to obtain correlations between anthropometric parameters, blood biochemical markers, and PFC.At baseline, PFC only showed a significant correlation with visceral adipose tissue (VAT) (r = 0.41). Relative changes in PFC were significantly (p = 0.01) greater in Q4 (-30.8 ± 5.7
LB  - PUB:(DE-HGF)16
C6  - pmid:31018616
DO  - DOI:10.3390/nu11040912
UR  - https://inrepo02.dkfz.de/record/143739
ER  -