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@ARTICLE{Jiang:143739,
      author       = {Y. Jiang and M. Spurny and R. Schübel$^*$ and T.
                      Nonnenmacher and C. L. Schlett and O. von Stackelberg and C.
                      M. Ulrich and R. Kaaks$^*$ and H.-U. Kauczor and T.
                      Kühn$^*$ and J. Nattenmüller},
      title        = {{C}hanges in {P}ancreatic {F}at {C}ontent {F}ollowing
                      {D}iet-{I}nduced {W}eight {L}oss.},
      journal      = {Nutrients},
      volume       = {11},
      number       = {4},
      issn         = {2072-6643},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2019-01308},
      pages        = {912},
      year         = {2019},
      abstract     = {Obesity can lead to ectopic pancreatic fat accumulation and
                      increase the risk for type 2 diabetes. Smaller intervention
                      trials have shown a decrease in pancreatic fat content (PFC)
                      with weight loss, and we intended to investigate the effects
                      of weight loss on PFC in a larger trial.Data from the
                      HELENA-Trial, a randomized controlled trial (RCT) among 137
                      non-diabetic obese adults were used. The study cohort was
                      classified into 4 quartiles based on weight change between
                      baseline and 12 weeks post-intervention. Changes in PFC
                      (baseline, 12 weeks and 50 weeks post-intervention) upon
                      weight loss were analyzed by linear mixed models. Spearman's
                      coefficients were used to obtain correlations between
                      anthropometric parameters, blood biochemical markers, and
                      PFC.At baseline, PFC only showed a significant correlation
                      with visceral adipose tissue (VAT) (r = 0.41). Relative
                      changes in PFC were significantly (p = 0.01) greater in Q4
                      (-30.8 ± $5.7\%)$ than in Q1 (1.3 ± $6.7\%).$ These
                      differences remained similar after one year. However, when
                      adjusting the statistical analyses for changes in VAT, the
                      differences in PFC between Q1 and Q4 were no longer
                      statistically significant.Weight loss is associated with a
                      decrease in PFC. However, the reduction of PFC is not
                      independent from reductions in VAT. Unlike VAT, PFC was not
                      associated with metabolic biomarkers.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31018616},
      doi          = {10.3390/nu11040912},
      url          = {https://inrepo02.dkfz.de/record/143739},
}