TY  - JOUR
AU  - Sasamoto, Naoko
AU  - Babic, Ana
AU  - Rosner, Bernard A
AU  - Turzanski-Fortner, Renée
AU  - Vitonis, Allison F
AU  - Yamamoto, Hidemi
AU  - Fichorova, Raina N
AU  - Tjønneland, Anne
AU  - Hansen, Louise
AU  - Overvad, Kim
AU  - Kvaskoff, Marina
AU  - Fournier, Agnès
AU  - Romana Mancini, Francesca
AU  - Boeing, Heiner
AU  - Trichopoulou, Antonia
AU  - Peppa, Eleni
AU  - Karakatsani, Anna
AU  - Palli, Domenico
AU  - Pala, Valeria
AU  - Mattiello, Amalia
AU  - Tumino, Rosario
AU  - Grasso, Chiara C
AU  - Onland-Moret, N Charlotte
AU  - Weiderpass, Elisabete
AU  - Quirós, J Ramón
AU  - Lujan-Barroso, Leila
AU  - Rodríguez-Barranco, Miguel
AU  - Colorado-Yohar, Sandra
AU  - Barricarte, Aurelio
AU  - Dorronsoro, Miren
AU  - Idahl, Annika
AU  - Lundin, Eva
AU  - Sartor, Hanna
AU  - Khaw, Kay-Tee
AU  - Key, Timothy J
AU  - Muller, David
AU  - Riboli, Elio
AU  - Gunter, Marc J
AU  - Dossus, Laure
AU  - Kaaks, Rudolf
AU  - Cramer, Daniel W
AU  - Tworoger, Shelley S
AU  - Terry, Kathryn L
TI  - Predicting Circulating CA125 Levels among Healthy Premenopausal Women.
JO  - Cancer epidemiology, biomarkers & prevention
VL  - 28
IS  - 6
SN  - 1538-7755
CY  - Philadelphia, Pa.
PB  - AACR
M1  - DKFZ-2019-01375
SP  - 1076 - 1085
PY  - 2019
AB  - Background: Cancer antigen 125 (CA125) is the most promising ovarian cancer screening biomarker to date. Multiple studies reported CA125 levels vary by personal characteristics, which could inform personalized CA125 thresholds. However, this has not been well described in premenopausal women.Methods: We evaluated predictors of CA125 levels among 815 premenopausal women from the New England Case Control Study (NEC). We developed linear and dichotomous (≥35 U/mL) CA125 prediction models and externally validated an abridged model restricting to available predictors among 473 premenopausal women in the European Prospective Investigation into Cancer and Nutrition Study (EPIC).Results: The final linear CA125 prediction model included age, race, tubal ligation, endometriosis, menstrual phase at blood draw, and fibroids, which explained 7
LB  - PUB:(DE-HGF)16
C6  - pmid:30948451
DO  - DOI:10.1158/1055-9965.EPI-18-1120
UR  - https://inrepo02.dkfz.de/record/143813
ER  -