Journal Article

DKFZ-2019-01375

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Predicting Circulating CA125 Levels among Healthy Premenopausal Women.

Sasamoto, N. ; Babic, A. ; Rosner, B. A. ; Turzanski-Fortner, R.DKFZ* ; Vitonis, A. F. ; Yamamoto, H. ; Fichorova, R. N. ; Tjønneland, A. ; Hansen, L. ; Overvad, K. ; Kvaskoff, M. ; Fournier, A. ; Romana Mancini, F. ; Boeing, H. ; Trichopoulou, A. ; Peppa, E. ; Karakatsani, A. ; Palli, D. ; Pala, V. ; Mattiello, A. ; Tumino, R. ; Grasso, C. C. ; Onland-Moret, N. C. ; Weiderpass, E. ; Quirós, J. R. ; Lujan-Barroso, L. ; Rodríguez-Barranco, M. ; Colorado-Yohar, S. ; Barricarte, A. ; Dorronsoro, M. ; Idahl, A. ; Lundin, E. ; Sartor, H. ; Khaw, K.-T. ; Key, T. J. ; Muller, D. ; Riboli, E. ; Gunter, M. J. ; Dossus, L. ; Kaaks, R.DKFZ* ; Cramer, D. W. ; Tworoger, S. S. ; Terry, K. L.

2019
AACR Philadelphia, Pa.

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Please use a persistent id in citations: doi:10.1158/1055-9965.EPI-18-1120

Abstract: Background: Cancer antigen 125 (CA125) is the most promising ovarian cancer screening biomarker to date. Multiple studies reported CA125 levels vary by personal characteristics, which could inform personalized CA125 thresholds. However, this has not been well described in premenopausal women.Methods: We evaluated predictors of CA125 levels among 815 premenopausal women from the New England Case Control Study (NEC). We developed linear and dichotomous (≥35 U/mL) CA125 prediction models and externally validated an abridged model restricting to available predictors among 473 premenopausal women in the European Prospective Investigation into Cancer and Nutrition Study (EPIC).Results: The final linear CA125 prediction model included age, race, tubal ligation, endometriosis, menstrual phase at blood draw, and fibroids, which explained 7% of the total variance of CA125. The correlation between observed and predicted CA125 levels based on the abridged model (including age, race, and menstrual phase at blood draw) had similar correlation coefficients in NEC (r = 0.22) and in EPIC (r = 0.22). The dichotomous CA125 prediction model included age, tubal ligation, endometriosis, prior personal cancer diagnosis, family history of ovarian cancer, number of miscarriages, menstrual phase at blood draw, and smoking status with AUC of 0.83. The abridged dichotomous model (including age, number of miscarriages, menstrual phase at blood draw, and smoking status) showed similar AUCs in NEC (0.73) and in EPIC (0.78).Conclusions: We identified a combination of factors associated with CA125 levels in premenopausal women.Impact: Our model could be valuable in identifying healthy women likely to have elevated CA125 and consequently improve its specificity for ovarian cancer screening.

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Contributing Institute(s):

1. Epidemiologie von Krebserkrankungen (C020)

Research Program(s):

1. 313 - Cancer risk factors and prevention (POF3-313) (POF3-313)

Appears in the scientific report 2019

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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