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000143906 1001_ $$aDi Credico, Gioia$$b0
000143906 245__ $$aJoint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: A bivariate spline model approach.
000143906 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2019
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000143906 520__ $$aThis study aimed at re-evaluating the strength and shape of the dose-response relationship between the combined (or joint) effect of intensity and duration of cigarette smoking and the risk of head and neck cancer (HNC). We explored this issue considering bivariate spline models, where smoking intensity and duration were treated as interacting continuous exposures.We pooled individual-level data from 33 case-control studies (18,260 HNC cases and 29,844 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. In bivariate regression spline models, exposures to cigarette smoking intensity and duration (compared with never smokers) were modeled as a linear piecewise function within a logistic regression also including potential confounders. We jointly estimated the optimal knot locations and regression parameters within the Bayesian framework.For oral-cavity/pharyngeal (OCP) cancers, an odds ratio (OR) >5 was reached after 30 years in current smokers of ∼20 or more cigarettes/day. Patterns of OCP cancer risk in current smokers differed across strata of alcohol intensity. For laryngeal cancer, ORs >20 were found for current smokers of ≥20 cigarettes/day for ≥30  years. In former smokers who quit ≥10  years ago, the ORs were approximately halved for OCP cancers, and ∼1/3 for laryngeal cancer, as compared to the same levels of intensity and duration in current smokers.Referring to bivariate spline models, this study better quantified the joint effect of intensity and duration of cigarette smoking on HNC risk, further stressing the need of smoking cessation policies.
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000143906 7001_ $$aEdefonti, Valeria$$b1
000143906 7001_ $$aPolesel, Jerry$$b2
000143906 7001_ $$aPauli, Francesco$$b3
000143906 7001_ $$aTorelli, Nicola$$b4
000143906 7001_ $$aSerraino, Diego$$b5
000143906 7001_ $$aNegri, Eva$$b6
000143906 7001_ $$aLuce, Daniele$$b7
000143906 7001_ $$aStucker, Isabelle$$b8
000143906 7001_ $$aMatsuo, Keitaro$$b9
000143906 7001_ $$aBrennan, Paul$$b10
000143906 7001_ $$aVilensky, Marta$$b11
000143906 7001_ $$aFernandez, Leticia$$b12
000143906 7001_ $$aCurado, Maria Paula$$b13
000143906 7001_ $$aMenezes, Ana$$b14
000143906 7001_ $$aDaudt, Alexander W$$b15
000143906 7001_ $$aKoifman, Rosalina$$b16
000143906 7001_ $$aWunsch-Filho, Victor$$b17
000143906 7001_ $$aHolcatova, Ivana$$b18
000143906 7001_ $$aAhrens, Wolfgang$$b19
000143906 7001_ $$aLagiou, Pagona$$b20
000143906 7001_ $$aSimonato, Lorenzo$$b21
000143906 7001_ $$aRichiardi, Lorenzo$$b22
000143906 7001_ $$aHealy, Claire$$b23
000143906 7001_ $$aKjaerheim, Kristina$$b24
000143906 7001_ $$aConway, David I$$b25
000143906 7001_ $$aMacfarlane, Tatiana V$$b26
000143906 7001_ $$aThomson, Peter$$b27
000143906 7001_ $$aAgudo, Antonio$$b28
000143906 7001_ $$aZnaor, Ariana$$b29
000143906 7001_ $$aBoaventura Rios, Leonardo F$$b30
000143906 7001_ $$aToporcov, Tatiana N$$b31
000143906 7001_ $$aFranceschi, Silvia$$b32
000143906 7001_ $$aHerrero, Rolando$$b33
000143906 7001_ $$aMuscat, Joshua$$b34
000143906 7001_ $$aOlshan, Andrew F$$b35
000143906 7001_ $$aZevallos, Jose P$$b36
000143906 7001_ $$aLa Vecchia, Carlo$$b37
000143906 7001_ $$aWinn, Deborah M$$b38
000143906 7001_ $$aSturgis, Erich M$$b39
000143906 7001_ $$aLi, Guojun$$b40
000143906 7001_ $$aFabianova, Eleonora$$b41
000143906 7001_ $$aLissowska, Jolanda$$b42
000143906 7001_ $$aMates, Dana$$b43
000143906 7001_ $$aRudnai, Peter$$b44
000143906 7001_ $$aShangina, Oxana$$b45
000143906 7001_ $$aSwiatkowska, Beata$$b46
000143906 7001_ $$aMoysich, Kirsten$$b47
000143906 7001_ $$aZhang, Zuo-Feng$$b48
000143906 7001_ $$aMorgenstern, Hal$$b49
000143906 7001_ $$aLevi, Fabio$$b50
000143906 7001_ $$aSmith, Elaine$$b51
000143906 7001_ $$aLazarus, Philip$$b52
000143906 7001_ $$aBosetti, Cristina$$b53
000143906 7001_ $$aGaravello, Werner$$b54
000143906 7001_ $$aKelsey, Karl$$b55
000143906 7001_ $$aMcClean, Michael$$b56
000143906 7001_ $$aRamroth, Heribert$$b57
000143906 7001_ $$aChen, Chu$$b58
000143906 7001_ $$aSchwartz, Stephen M$$b59
000143906 7001_ $$aVaughan, Thomas L$$b60
000143906 7001_ $$aZheng, Tongzhang$$b61
000143906 7001_ $$aMenvielle, Gwenn$$b62
000143906 7001_ $$aBoccia, Stefania$$b63
000143906 7001_ $$aCadoni, Gabriella$$b64
000143906 7001_ $$aHayes, Richard B$$b65
000143906 7001_ $$aPurdue, Mark$$b66
000143906 7001_ $$aGillison, Maura$$b67
000143906 7001_ $$aSchantz, Stimson$$b68
000143906 7001_ $$aYu, Guo-Pei$$b69
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000143906 7001_ $$aChuang, Shu-Chun$$b73
000143906 7001_ $$aBoffetta, Paolo$$b74
000143906 7001_ $$aHashibe, Mia$$b75
000143906 7001_ $$aLee, Yuan-Chin Amy$$b76
000143906 7001_ $$aDal Maso, Luigino$$b77
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