Journal Article

DKFZ-2019-01464

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: A bivariate spline model approach.

Di Credico, G. ; Edefonti, V. ; Polesel, J. ; Pauli, F. ; Torelli, N. ; Serraino, D. ; Negri, E. ; Luce, D. ; Stucker, I. ; Matsuo, K. ; Brennan, P. ; Vilensky, M. ; Fernandez, L. ; Curado, M. P. ; Menezes, A. ; Daudt, A. W. ; Koifman, R. ; Wunsch-Filho, V. ; Holcatova, I. ; Ahrens, W. ; Lagiou, P. ; Simonato, L. ; Richiardi, L. ; Healy, C. ; Kjaerheim, K. ; Conway, D. I. ; Macfarlane, T. V. ; Thomson, P. ; Agudo, A. ; Znaor, A. ; Boaventura Rios, L. F. ; Toporcov, T. N. ; Franceschi, S. ; Herrero, R. ; Muscat, J. ; Olshan, A. F. ; Zevallos, J. P. ; La Vecchia, C. ; Winn, D. M. ; Sturgis, E. M. ; Li, G. ; Fabianova, E. ; Lissowska, J. ; Mates, D. ; Rudnai, P. ; Shangina, O. ; Swiatkowska, B. ; Moysich, K. ; Zhang, Z.-F. ; Morgenstern, H. ; Levi, F. ; Smith, E. ; Lazarus, P. ; Bosetti, C. ; Garavello, W. ; Kelsey, K. ; McClean, M. ; Ramroth, H. ; Chen, C. ; Schwartz, S. M. ; Vaughan, T. L. ; Zheng, T. ; Menvielle, G. ; Boccia, S. ; Cadoni, G. ; Hayes, R. B. ; Purdue, M. ; Gillison, M. ; Schantz, S. ; Yu, G.-P. ; Brenner, H.DKFZ* ; D'Souza, G. ; Gross, N. D. ; Chuang, S.-C. ; Boffetta, P. ; Hashibe, M. ; Lee, Y. A. ; Dal Maso, L.

2019
Elsevier Science Amsterdam [u.a.]

This record in other databases:  

Please use a persistent id in citations: doi:10.1016/j.oraloncology.2019.05.006

Abstract: This study aimed at re-evaluating the strength and shape of the dose-response relationship between the combined (or joint) effect of intensity and duration of cigarette smoking and the risk of head and neck cancer (HNC). We explored this issue considering bivariate spline models, where smoking intensity and duration were treated as interacting continuous exposures.We pooled individual-level data from 33 case-control studies (18,260 HNC cases and 29,844 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. In bivariate regression spline models, exposures to cigarette smoking intensity and duration (compared with never smokers) were modeled as a linear piecewise function within a logistic regression also including potential confounders. We jointly estimated the optimal knot locations and regression parameters within the Bayesian framework.For oral-cavity/pharyngeal (OCP) cancers, an odds ratio (OR) >5 was reached after 30 years in current smokers of ∼20 or more cigarettes/day. Patterns of OCP cancer risk in current smokers differed across strata of alcohol intensity. For laryngeal cancer, ORs >20 were found for current smokers of ≥20 cigarettes/day for ≥30  years. In former smokers who quit ≥10  years ago, the ORs were approximately halved for OCP cancers, and ∼1/3 for laryngeal cancer, as compared to the same levels of intensity and duration in current smokers.Referring to bivariate spline models, this study better quantified the joint effect of intensity and duration of cigarette smoking on HNC risk, further stressing the need of smoking cessation policies.

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Contributing Institute(s):

1. Klinische Epidemiologie und Alternsforschung (C070)
2. Präventive Onkologie (C120)
3. DKTK Heidelberg (L101)

Research Program(s):

1. 313 - Cancer risk factors and prevention (POF3-313) (POF3-313)

Appears in the scientific report 2019

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Ebsco Academic Search ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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