TY  - JOUR
AU  - Di Credico, Gioia
AU  - Edefonti, Valeria
AU  - Polesel, Jerry
AU  - Pauli, Francesco
AU  - Torelli, Nicola
AU  - Serraino, Diego
AU  - Negri, Eva
AU  - Luce, Daniele
AU  - Stucker, Isabelle
AU  - Matsuo, Keitaro
AU  - Brennan, Paul
AU  - Vilensky, Marta
AU  - Fernandez, Leticia
AU  - Curado, Maria Paula
AU  - Menezes, Ana
AU  - Daudt, Alexander W
AU  - Koifman, Rosalina
AU  - Wunsch-Filho, Victor
AU  - Holcatova, Ivana
AU  - Ahrens, Wolfgang
AU  - Lagiou, Pagona
AU  - Simonato, Lorenzo
AU  - Richiardi, Lorenzo
AU  - Healy, Claire
AU  - Kjaerheim, Kristina
AU  - Conway, David I
AU  - Macfarlane, Tatiana V
AU  - Thomson, Peter
AU  - Agudo, Antonio
AU  - Znaor, Ariana
AU  - Boaventura Rios, Leonardo F
AU  - Toporcov, Tatiana N
AU  - Franceschi, Silvia
AU  - Herrero, Rolando
AU  - Muscat, Joshua
AU  - Olshan, Andrew F
AU  - Zevallos, Jose P
AU  - La Vecchia, Carlo
AU  - Winn, Deborah M
AU  - Sturgis, Erich M
AU  - Li, Guojun
AU  - Fabianova, Eleonora
AU  - Lissowska, Jolanda
AU  - Mates, Dana
AU  - Rudnai, Peter
AU  - Shangina, Oxana
AU  - Swiatkowska, Beata
AU  - Moysich, Kirsten
AU  - Zhang, Zuo-Feng
AU  - Morgenstern, Hal
AU  - Levi, Fabio
AU  - Smith, Elaine
AU  - Lazarus, Philip
AU  - Bosetti, Cristina
AU  - Garavello, Werner
AU  - Kelsey, Karl
AU  - McClean, Michael
AU  - Ramroth, Heribert
AU  - Chen, Chu
AU  - Schwartz, Stephen M
AU  - Vaughan, Thomas L
AU  - Zheng, Tongzhang
AU  - Menvielle, Gwenn
AU  - Boccia, Stefania
AU  - Cadoni, Gabriella
AU  - Hayes, Richard B
AU  - Purdue, Mark
AU  - Gillison, Maura
AU  - Schantz, Stimson
AU  - Yu, Guo-Pei
AU  - Brenner, Hermann
AU  - D'Souza, Gypsyamber
AU  - Gross, Neil D
AU  - Chuang, Shu-Chun
AU  - Boffetta, Paolo
AU  - Hashibe, Mia
AU  - Lee, Yuan-Chin Amy
AU  - Dal Maso, Luigino
TI  - Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: A bivariate spline model approach.
JO  - Oral oncology
VL  - 94
SN  - 1368-8375
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DKFZ-2019-01464
SP  - 47 - 57
PY  - 2019
AB  - This study aimed at re-evaluating the strength and shape of the dose-response relationship between the combined (or joint) effect of intensity and duration of cigarette smoking and the risk of head and neck cancer (HNC). We explored this issue considering bivariate spline models, where smoking intensity and duration were treated as interacting continuous exposures.We pooled individual-level data from 33 case-control studies (18,260 HNC cases and 29,844 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. In bivariate regression spline models, exposures to cigarette smoking intensity and duration (compared with never smokers) were modeled as a linear piecewise function within a logistic regression also including potential confounders. We jointly estimated the optimal knot locations and regression parameters within the Bayesian framework.For oral-cavity/pharyngeal (OCP) cancers, an odds ratio (OR) >5 was reached after 30 years in current smokers of ∼20 or more cigarettes/day. Patterns of OCP cancer risk in current smokers differed across strata of alcohol intensity. For laryngeal cancer, ORs >20 were found for current smokers of ≥20 cigarettes/day for ≥30  years. In former smokers who quit ≥10  years ago, the ORs were approximately halved for OCP cancers, and ∼1/3 for laryngeal cancer, as compared to the same levels of intensity and duration in current smokers.Referring to bivariate spline models, this study better quantified the joint effect of intensity and duration of cigarette smoking on HNC risk, further stressing the need of smoking cessation policies.
LB  - PUB:(DE-HGF)16
C6  - pmid:31178212
DO  - DOI:10.1016/j.oraloncology.2019.05.006
UR  - https://inrepo02.dkfz.de/record/143906
ER  -