% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{DiCredico:143906,
      author       = {G. Di Credico and V. Edefonti and J. Polesel and F. Pauli
                      and N. Torelli and D. Serraino and E. Negri and D. Luce and
                      I. Stucker and K. Matsuo and P. Brennan and M. Vilensky and
                      L. Fernandez and M. P. Curado and A. Menezes and A. W. Daudt
                      and R. Koifman and V. Wunsch-Filho and I. Holcatova and W.
                      Ahrens and P. Lagiou and L. Simonato and L. Richiardi and C.
                      Healy and K. Kjaerheim and D. I. Conway and T. V. Macfarlane
                      and P. Thomson and A. Agudo and A. Znaor and L. F.
                      Boaventura Rios and T. N. Toporcov and S. Franceschi and R.
                      Herrero and J. Muscat and A. F. Olshan and J. P. Zevallos
                      and C. La Vecchia and D. M. Winn and E. M. Sturgis and G. Li
                      and E. Fabianova and J. Lissowska and D. Mates and P. Rudnai
                      and O. Shangina and B. Swiatkowska and K. Moysich and Z.-F.
                      Zhang and H. Morgenstern and F. Levi and E. Smith and P.
                      Lazarus and C. Bosetti and W. Garavello and K. Kelsey and M.
                      McClean and H. Ramroth and C. Chen and S. M. Schwartz and T.
                      L. Vaughan and T. Zheng and G. Menvielle and S. Boccia and
                      G. Cadoni and R. B. Hayes and M. Purdue and M. Gillison and
                      S. Schantz and G.-P. Yu and H. Brenner$^*$ and G. D'Souza
                      and N. D. Gross and S.-C. Chuang and P. Boffetta and M.
                      Hashibe and Y. A. Lee and L. Dal Maso},
      title        = {{J}oint effects of intensity and duration of cigarette
                      smoking on the risk of head and neck cancer: {A} bivariate
                      spline model approach.},
      journal      = {Oral oncology},
      volume       = {94},
      issn         = {1368-8375},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2019-01464},
      pages        = {47 - 57},
      year         = {2019},
      abstract     = {This study aimed at re-evaluating the strength and shape of
                      the dose-response relationship between the combined (or
                      joint) effect of intensity and duration of cigarette smoking
                      and the risk of head and neck cancer (HNC). We explored this
                      issue considering bivariate spline models, where smoking
                      intensity and duration were treated as interacting
                      continuous exposures.We pooled individual-level data from 33
                      case-control studies (18,260 HNC cases and 29,844 controls)
                      participating in the International Head and Neck Cancer
                      Epidemiology (INHANCE) consortium. In bivariate regression
                      spline models, exposures to cigarette smoking intensity and
                      duration (compared with never smokers) were modeled as a
                      linear piecewise function within a logistic regression also
                      including potential confounders. We jointly estimated the
                      optimal knot locations and regression parameters within the
                      Bayesian framework.For oral-cavity/pharyngeal (OCP) cancers,
                      an odds ratio (OR) >5 was reached after 30 years in
                      current smokers of ∼20 or more cigarettes/day. Patterns of
                      OCP cancer risk in current smokers differed across strata of
                      alcohol intensity. For laryngeal cancer, ORs >20 were found
                      for current smokers of ≥20 cigarettes/day for ≥30 
                      years. In former smokers who quit ≥10  years ago, the
                      ORs were approximately halved for OCP cancers, and ∼1/3
                      for laryngeal cancer, as compared to the same levels of
                      intensity and duration in current smokers.Referring to
                      bivariate spline models, this study better quantified the
                      joint effect of intensity and duration of cigarette smoking
                      on HNC risk, further stressing the need of smoking cessation
                      policies.},
      cin          = {C070 / C120 / L101},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)L101-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31178212},
      doi          = {10.1016/j.oraloncology.2019.05.006},
      url          = {https://inrepo02.dkfz.de/record/143906},
}