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000143933 041__ $$aeng
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000143933 1001_ $$aCirera, Lluís$$b0
000143933 245__ $$aSocioeconomic Effect of Education on Pancreatic Cancer Risk in Western Europe: An Update on the EPIC Cohorts Study.
000143933 260__ $$aPhiladelphia, Pa.$$bAACR$$c2019
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000143933 520__ $$aTo analyze the potential effect of social inequality on pancreatic cancer risk in Western Europe, by reassessing the association within the European Prospective Investigation into Cancer and Nutrition (EPIC) Study, including a larger number of cases and an extended follow-up.Data on highest education attained were gathered for 459,170 participants (70% women) from 10 European countries. A relative index of inequality (RII) based on adult education was calculated for comparability across countries and generations. Cox regression models were applied to estimate relative inequality in pancreatic cancer risk, stratifying by age, gender, and center, and adjusting for known pancreatic cancer risk factors.A total of 1,223 incident pancreatic cancer cases were included after a mean follow-up of 13.9 (±4.0) years. An inverse social trend was found in models adjusted for age, sex, and center for both sexes [HR of RII, 1.27; 95% confidence interval (CI), 1.02-1.59], which was also significant among women (HR, 1.42; 95% CI, 1.05-1.92). Further adjusting by smoking intensity, alcohol consumption, body mass index, prevalent diabetes, and physical activity led to an attenuation of the RII risk and loss of statistical significance.The present reanalysis does not sustain the existence of an independent social inequality influence on pancreatic cancer risk in Western European women and men, using an index based on adult education, the most relevant social indicator linked to individual lifestyles, in a context of very low pancreatic cancer survival from (quasi) universal public health systems.The results do not support an association between education and risk of pancreatic cancer.
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000143933 7001_ $$00000-0002-9637-3869$$aHuerta, José María$$b1
000143933 7001_ $$aChirlaque, María Dolores$$b2
000143933 7001_ $$aOvervad, Kim$$b3
000143933 7001_ $$aLindström, Martin$$b4
000143933 7001_ $$00000-0001-7505-5880$$aRegnér, Sara$$b5
000143933 7001_ $$00000-0003-4385-2097$$aTjønneland, Anne$$b6
000143933 7001_ $$00000-0002-5956-5693$$aBoutron-Ruault, Marie-Christine$$b7
000143933 7001_ $$aRebours, Vinciane$$b8
000143933 7001_ $$aFagherazzi, Guy$$b9
000143933 7001_ $$0P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4$$aKatzke, Verena A$$b10$$udkfz
000143933 7001_ $$aBoeing, Heiner$$b11
000143933 7001_ $$aPeppa, Eleni$$b12
000143933 7001_ $$aTrichopoulou, Antonia$$b13
000143933 7001_ $$00000-0003-1970-6460$$aValanou, Elissavet$$b14
000143933 7001_ $$00000-0002-5558-2437$$aPalli, Domenico$$b15
000143933 7001_ $$00000-0002-5891-8426$$aGrioni, Sara$$b16
000143933 7001_ $$aPanico, Salvatore$$b17
000143933 7001_ $$00000-0003-2666-414X$$aTumino, Rosario$$b18
000143933 7001_ $$00000-0001-8749-9737$$aRicceri, Fulvio$$b19
000143933 7001_ $$00000-0003-0817-7567$$avan Gils, Carla$$b20
000143933 7001_ $$aVermeulen, Roel C H$$b21
000143933 7001_ $$00000-0003-2476-4251$$aSkeie, Guri$$b22
000143933 7001_ $$aBraaten, Tonje$$b23
000143933 7001_ $$00000-0003-2237-0128$$aWeiderpass, Elisabete$$b24
000143933 7001_ $$aMerino, Susana$$b25
000143933 7001_ $$aSánchez, María José$$b26
000143933 7001_ $$aLarrañaga, Nerea$$b27
000143933 7001_ $$aArdanaz, Eva$$b28
000143933 7001_ $$aSund, Malin$$b29
000143933 7001_ $$aKhaw, Kay-Tee$$b30
000143933 7001_ $$aKey, Timothy J$$b31
000143933 7001_ $$aJenab, Mazda$$b32
000143933 7001_ $$00000-0003-1049-6225$$aNaudin, Sabine$$b33
000143933 7001_ $$aMurphy, Neil$$b34
000143933 7001_ $$aAune, Dagfinn$$b35
000143933 7001_ $$aWard, Heather$$b36
000143933 7001_ $$aRiboli, Elio$$b37
000143933 7001_ $$aBueno-de-Mesquita, Bas$$b38
000143933 7001_ $$00000-0001-8896-7483$$aNavarro, Carmen$$b39
000143933 7001_ $$00000-0001-5256-0163$$aDuell, Eric J$$b40
000143933 773__ $$0PERI:(DE-600)2036781-8$$a10.1158/1055-9965.EPI-18-1153$$gVol. 28, no. 6, p. 1089 - 1092$$n6$$p1089 - 1092$$tCancer epidemiology, biomarkers & prevention$$v28$$x1538-7755$$y2019
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