Journal Article

DKFZ-2019-01490

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Socioeconomic Effect of Education on Pancreatic Cancer Risk in Western Europe: An Update on the EPIC Cohorts Study.

Cirera, L. ; Huerta, J. M. ; Chirlaque, M. D. ; Overvad, K. ; Lindström, M. ; Regnér, S. ; Tjønneland, A. ; Boutron-Ruault, M.-C. ; Rebours, V. ; Fagherazzi, G. ; Katzke, V. A.DKFZ* ; Boeing, H. ; Peppa, E. ; Trichopoulou, A. ; Valanou, E. ; Palli, D. ; Grioni, S. ; Panico, S. ; Tumino, R. ; Ricceri, F. ; van Gils, C. ; Vermeulen, R. C. H. ; Skeie, G. ; Braaten, T. ; Weiderpass, E. ; Merino, S. ; Sánchez, M. J. ; Larrañaga, N. ; Ardanaz, E. ; Sund, M. ; Khaw, K.-T. ; Key, T. J. ; Jenab, M. ; Naudin, S. ; Murphy, N. ; Aune, D. ; Ward, H. ; Riboli, E. ; Bueno-de-Mesquita, B. ; Navarro, C. ; Duell, E. J.

2019
AACR Philadelphia, Pa.

This record in other databases:  

Please use a persistent id in citations: doi:10.1158/1055-9965.EPI-18-1153

Abstract: To analyze the potential effect of social inequality on pancreatic cancer risk in Western Europe, by reassessing the association within the European Prospective Investigation into Cancer and Nutrition (EPIC) Study, including a larger number of cases and an extended follow-up.Data on highest education attained were gathered for 459,170 participants (70% women) from 10 European countries. A relative index of inequality (RII) based on adult education was calculated for comparability across countries and generations. Cox regression models were applied to estimate relative inequality in pancreatic cancer risk, stratifying by age, gender, and center, and adjusting for known pancreatic cancer risk factors.A total of 1,223 incident pancreatic cancer cases were included after a mean follow-up of 13.9 (±4.0) years. An inverse social trend was found in models adjusted for age, sex, and center for both sexes [HR of RII, 1.27; 95% confidence interval (CI), 1.02-1.59], which was also significant among women (HR, 1.42; 95% CI, 1.05-1.92). Further adjusting by smoking intensity, alcohol consumption, body mass index, prevalent diabetes, and physical activity led to an attenuation of the RII risk and loss of statistical significance.The present reanalysis does not sustain the existence of an independent social inequality influence on pancreatic cancer risk in Western European women and men, using an index based on adult education, the most relevant social indicator linked to individual lifestyles, in a context of very low pancreatic cancer survival from (quasi) universal public health systems.The results do not support an association between education and risk of pancreatic cancer.

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Contributing Institute(s):

1. Epidemiologie von Krebserkrankungen (C020)

Research Program(s):

1. 313 - Cancer risk factors and prevention (POF3-313) (POF3-313)

Appears in the scientific report 2019

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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