Journal Article

DKFZ-2019-01685

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Cardiorenal sodium MRI at 7.0 Tesla using a 4/4 channel 1H/23Na radiofrequency antenna array

Boehmert, L. ; Kuehne, A. ; Waiczies, H. ; Wenz, D. ; Eigentler, T. W. ; Funk, S. ; von Knobelsdorff-Brenkenhoff, F. ; Schulz-Menger, J. ; Nagel, A. M.DKFZ* ; Seeliger, E. ; Niendorf, T.

2019
Wiley-Liss New York, NY [u.a.]

Abstract: Cardiorenal syndrome describes disorders of the heart and the kidneys in which a dysfunction of 1 organ induces a dysfunction in the other. This work describes the design, evaluation, and application of a 4/4-channel hydrogen-1/sodium (1 H/23 Na) RF array tailored for cardiorenal MRI at 7.0 Tesla (T) for a better physiometabolic understanding of cardiorenal syndrome.The dual-frequency RF array is composed of a planar posterior section and a modestly curved anterior section, each section consisting of 2 loop elements tailored for 23 Na MR and 2 loopole-type elements customized for 1 H MR. Numerical electromagnetic field and specific absorption rate simulations were carried out. Transmission field ( B 1 + ) uniformity was optimized and benchmarked against electromagnetic field simulations. An in vivo feasibility study was performed.The proposed array exhibits sufficient RF characteristics, B 1 + homogeneity, and penetration depth to perform 23 Na MRI of the heart and kidney at 7.0 T. The mean B 1 + field for sodium in the heart is 7.7 ± 0.8 µT/√kW and in the kidney is 6.9 ± 2.3 µT/√kW. The suitability of the RF array for 23 Na MRI was demonstrated in healthy subjects (acquisition time for 23 Na MRI: 18 min; nominal isotropic spatial resolution: 5 mm [kidney] and 6 mm [heart]).This work provides encouragement for further explorations into densely packed multichannel transceiver arrays tailored for 23 Na MRI of the heart and kidney. Equipped with this technology, the ability to probe sodium concentration in the heart and kidney in vivo using 23 Na MRI stands to make a critical contribution to deciphering the complex interactions between both organs.

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Contributing Institute(s):

1. Medizinische Physik in der Radiologie (E020)

Research Program(s):

1. 315 - Imaging and radiooncology (POF3-315) (POF3-315)

Appears in the scientific report 2019

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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