% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{FreireValls:144155,
      author       = {A. Freire Valls and K. Knipper and E. Giannakouri and V.
                      Sarachaga and S. Hinterkopf and M. Wuehrl and Y. Shen and P.
                      Radhakrishnan and J. Klose and A. Ulrich and M. Schneider
                      and H. Augustin$^*$ and C. Ruiz de Almodovar and T. Schmidt},
      title        = {{VEGFR}1+ metastasis-associated macrophages contribute to
                      metastatic angiogenesis and influence colorectal cancer
                      patient outcome.311},
      journal      = {Clinical cancer research},
      volume       = {25},
      number       = {18},
      issn         = {1557-3265},
      address      = {Philadelphia, Pa. [u.a.]},
      publisher    = {AACR},
      reportid     = {DKFZ-2019-01704},
      pages        = {5674-5685},
      year         = {2019},
      note         = {DKFZ-ZMBH Alliance},
      abstract     = {To investigate the clinical relevance of macrophages in
                      liver metastasis of colorectal cancer and their influence on
                      angiogenesis and patient survival. Moreover, to evaluate
                      specific blood monocytes as markers of disease recurrence.In
                      a mouse model with spontaneous LM, the angiogenic
                      characteristics of tumor- (TAMs) and metastasis- (MAMs)
                      associated macrophages were evaluated. Macrophages and the
                      vasculature from 130 primary tumor (pTU) and 123 liver
                      metastasis (LM) patients were assessed. In vivo and in human
                      samples, the clinical relevance of macrophage VEGFR1
                      expression was analyzed. Blood samples from patients (n =
                      157, 80 pTU and 77 LM) were analyzed for assessing VEGFR1+
                      cells as suitable biomarkers of disease recurrence.The
                      number of macrophages positively correlated with
                      vascularization in metastasis. Both in the murine model as
                      well as in primary isolated human cells, a sub-population of
                      MAMs expressing VEGFR1 were found highly angiogenic. While
                      VEGFR1 expression in pTU patients did not predict prognosis;
                      high percentage of VEGFR1+ cells in LM was associated with
                      worse patient outcome. Interestingly, VEGFR1+ circulating
                      monocytes in blood samples from LM patients not only
                      predicted progression but also site of recurrence.Our
                      findings identify a new subset of pro-angiogenic VEGFR1+
                      MAMs in colorectal cancer that support metastatic growth and
                      may become a liquid biomarker to predict disease recurrence
                      in the liver.},
      cin          = {A190},
      ddc          = {610},
      cid          = {I:(DE-He78)A190-20160331},
      pnm          = {311 - Signalling pathways, cell and tumor biology
                      (POF3-311)},
      pid          = {G:(DE-HGF)POF3-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31239322},
      doi          = {10.1158/1078-0432.CCR-18-2123},
      url          = {https://inrepo02.dkfz.de/record/144155},
}