Journal Article

DKFZ-2019-01704

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png VEGFR1+ metastasis-associated macrophages contribute to metastatic angiogenesis and influence colorectal cancer patient outcome.311

Freire Valls, A. ; Knipper, K. ; Giannakouri, E. ; Sarachaga, V. ; Hinterkopf, S. ; Wuehrl, M. ; Shen, Y. ; Radhakrishnan, P. ; Klose, J. ; Ulrich, A. ; Schneider, M. ; Augustin, H.DKFZ* ; Ruiz de Almodovar, C. ; Schmidt, T.

2019
AACR Philadelphia, Pa. [u.a.]

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Please use a persistent id in citations: doi:10.1158/1078-0432.CCR-18-2123

Abstract: To investigate the clinical relevance of macrophages in liver metastasis of colorectal cancer and their influence on angiogenesis and patient survival. Moreover, to evaluate specific blood monocytes as markers of disease recurrence.In a mouse model with spontaneous LM, the angiogenic characteristics of tumor- (TAMs) and metastasis- (MAMs) associated macrophages were evaluated. Macrophages and the vasculature from 130 primary tumor (pTU) and 123 liver metastasis (LM) patients were assessed. In vivo and in human samples, the clinical relevance of macrophage VEGFR1 expression was analyzed. Blood samples from patients (n = 157, 80 pTU and 77 LM) were analyzed for assessing VEGFR1+ cells as suitable biomarkers of disease recurrence.The number of macrophages positively correlated with vascularization in metastasis. Both in the murine model as well as in primary isolated human cells, a sub-population of MAMs expressing VEGFR1 were found highly angiogenic. While VEGFR1 expression in pTU patients did not predict prognosis; high percentage of VEGFR1+ cells in LM was associated with worse patient outcome. Interestingly, VEGFR1+ circulating monocytes in blood samples from LM patients not only predicted progression but also site of recurrence.Our findings identify a new subset of pro-angiogenic VEGFR1+ MAMs in colorectal cancer that support metastatic growth and may become a liquid biomarker to predict disease recurrence in the liver.

Note: DKFZ-ZMBH Alliance

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Contributing Institute(s):

1. Vaskuläre Onkologie und Metastasierung (A190)

Research Program(s):

1. 311 - Signalling pathways, cell and tumor biology (POF3-311) (POF3-311)

Appears in the scientific report 2019

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; IF >= 10 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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