Journal Article

DKFZ-2019-01952

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Assessment of Melanin Content and its Influence on Susceptibility Contrast in Melanoma Metastases.

Straub, S. (First author)DKFZ* ; Laun, F. B.DKFZ* ; Freitag, M. T.DKFZ* ; Kölsche, C.DKFZ* ; von Deimling, A.DKFZ* ; Denoix, M.DKFZ* ; Bendszus, M. ; Schlemmer, H.-P.DKFZ* ; Ladd, M. E.DKFZ* ; Schneider, T. (Last author)DKFZ*

2020
Urban & Vogel München

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Please use a persistent id in citations: doi:10.1007/s00062-019-00816-x

Abstract: To quantify the influence of melanin content on magnetic susceptibility of cerebral melanoma metastases.Patients with non-hemorrhagic metastases were included based on the absence of susceptibility blooming artifacts. Susceptibility maps were calculated from 3D gradient echo data, using Laplacian-based phase unwrapping, sophisticated harmonic artefact reduction for phase data (V-SHARP) with varying spherical kernel sizes for background field removal and the iLSQR algorithm for the inversion of phase data. Susceptibility maps were referenced to cerebrospinal fluid. Non-hemorrhagic metastases were identified on contrast-enhanced T1-weighted images and susceptibility weighted images. Metastases masks were drawn on T1-weighted post-contrast images and used to compute mean susceptibility values of each metastasis.A total of 33 non-hemorrhagic melanoma brain metastases in 20 patients were quantitatively evaluated. Metastases without and with hyperintense signal on T1-weighted images, which corresponds to the melanin content, showed median susceptibility values of -0.028 ppm and -0.020 ppm, respectively. The susceptibility differences between metastases without and with T1-weighted hyperintense signal was not statistically significant (p ≥ 0.05).Non-hemorrhagic cerebral melanoma metastases showed weak diamagnetic susceptibility values and susceptibility did not significantly correlate to T1-weighted signals. Therefore, melanin does not seem to be a major contributor to susceptibility in cerebral melanoma metastases.

Note: 2020 Sep;30(3):607-614#EA:E020#LA:E010#

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Contributing Institute(s):

1. E020 Med. Physik in der Radiologie (E020)
2. E010 Radiologie (E010)
3. KKE Neuropathologie (B300)
4. DKTK HD zentral (HD01)

Research Program(s):

1. 315 - Imaging and radiooncology (POF3-315) (POF3-315)

Appears in the scientific report 2020

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Database coverage:
; Clarivate Analytics Master Journal List ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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