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000144661 1001_ $$aPahl, Jens H W$$b0
000144661 245__ $$aMemory-Like NK Cells: Remembering a Previous Activation by Cytokines and NK Cell Receptors.
000144661 260__ $$aLausanne$$bFrontiers Media$$c2018
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000144661 520__ $$aNatural Killer (NK) cells are cytotoxic innate lymphoid cells serving at the front line against infection and cancer. In inflammatory microenvironments, multiple soluble and contact-dependent signals modulate NK cell responsiveness. Besides their innate cytotoxic and immunostimulatory activity, it has been uncovered in recent years that NK cells constitute a heterogeneous and versatile cell subset. Persistent memory-like NK populations that mount a robust recall response were reported during viral infection, contact hypersensitivity reactions, and after stimulation by pro-inflammatory cytokines or activating receptor pathways. In this review, we highlight recent findings on the generation, functionality, and clinical applicability of memory-like NK cells and describe common features in comparison to other recent concepts of memory NK cells. Understanding of these features will facilitate the conception and design of novel NK cell-based immunotherapies.
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000144661 7001_ $$aCerwenka, Adelheid$$b1
000144661 7001_ $$0P:(DE-He78)e6c151d449e1db05b1ffb5ad5ec656cf$$aNi, Jing$$b2$$eLast author$$udkfz
000144661 773__ $$0PERI:(DE-600)2606827-8$$a10.3389/fimmu.2018.02796$$gVol. 9, p. 2796$$p2796$$tFrontiers in immunology$$v9$$x1664-3224$$y2018
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