Journal Article (Review Article)

DKFZ-2019-02103

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Memory-Like NK Cells: Remembering a Previous Activation by Cytokines and NK Cell Receptors.

Pahl, J. H. W. ; Cerwenka, A. ; Ni, J. (Last author)DKFZ*

2018
Frontiers Media Lausanne

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Please use a persistent id in citations: doi:10.3389/fimmu.2018.02796

Abstract: Natural Killer (NK) cells are cytotoxic innate lymphoid cells serving at the front line against infection and cancer. In inflammatory microenvironments, multiple soluble and contact-dependent signals modulate NK cell responsiveness. Besides their innate cytotoxic and immunostimulatory activity, it has been uncovered in recent years that NK cells constitute a heterogeneous and versatile cell subset. Persistent memory-like NK populations that mount a robust recall response were reported during viral infection, contact hypersensitivity reactions, and after stimulation by pro-inflammatory cytokines or activating receptor pathways. In this review, we highlight recent findings on the generation, functionality, and clinical applicability of memory-like NK cells and describe common features in comparison to other recent concepts of memory NK cells. Understanding of these features will facilitate the conception and design of novel NK cell-based immunotherapies.

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Contributing Institute(s):

1. Nachwuchsgruppe Angeborene Immunität (D080)
2. DKTK Heidelberg (L101)

Research Program(s):

1. 314 - Tumor immunology (POF3-314) (POF3-314)

Appears in the scientific report 2018

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; DOAJ Seal ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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