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@ARTICLE{Pahl:144661,
      author       = {J. H. W. Pahl and A. Cerwenka and J. Ni$^*$},
      title        = {{M}emory-{L}ike {NK} {C}ells: {R}emembering a {P}revious
                      {A}ctivation by {C}ytokines and {NK} {C}ell {R}eceptors.},
      journal      = {Frontiers in immunology},
      volume       = {9},
      issn         = {1664-3224},
      address      = {Lausanne},
      publisher    = {Frontiers Media},
      reportid     = {DKFZ-2019-02103},
      pages        = {2796},
      year         = {2018},
      abstract     = {Natural Killer (NK) cells are cytotoxic innate lymphoid
                      cells serving at the front line against infection and
                      cancer. In inflammatory microenvironments, multiple soluble
                      and contact-dependent signals modulate NK cell
                      responsiveness. Besides their innate cytotoxic and
                      immunostimulatory activity, it has been uncovered in recent
                      years that NK cells constitute a heterogeneous and versatile
                      cell subset. Persistent memory-like NK populations that
                      mount a robust recall response were reported during viral
                      infection, contact hypersensitivity reactions, and after
                      stimulation by pro-inflammatory cytokines or activating
                      receptor pathways. In this review, we highlight recent
                      findings on the generation, functionality, and clinical
                      applicability of memory-like NK cells and describe common
                      features in comparison to other recent concepts of memory NK
                      cells. Understanding of these features will facilitate the
                      conception and design of novel NK cell-based
                      immunotherapies.},
      subtyp        = {Review Article},
      cin          = {D080 / L101},
      ddc          = {610},
      cid          = {I:(DE-He78)D080-20160331 / I:(DE-He78)L101-20160331},
      pnm          = {314 - Tumor immunology (POF3-314)},
      pid          = {G:(DE-HGF)POF3-314},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30546366},
      pmc          = {pmc:PMC6279934},
      doi          = {10.3389/fimmu.2018.02796},
      url          = {https://inrepo02.dkfz.de/record/144661},
}