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| Home > Publications database > The transcription factor FOXM1 regulates the balance between proliferation and aberrant differentiation in head and neck squamous cell carcinoma. > print |
| Home > Publications database > The transcription factor FOXM1 regulates the balance between proliferation and aberrant differentiation in head and neck squamous cell carcinoma. > print |
| 001 | 144698 | ||
| 005 | 20240229123020.0 | ||
| 024 | 7 | _ | |a 10.1002/path.5342 |2 doi |
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| 024 | 7 | _ | |a 0368-3494 |2 ISSN |
| 024 | 7 | _ | |a 1096-9896 |2 ISSN |
| 024 | 7 | _ | |a 1555-2039 |2 ISSN |
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| 037 | _ | _ | |a DKFZ-2019-02140 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Roh, Vincent |b 0 |
| 245 | _ | _ | |a The transcription factor FOXM1 regulates the balance between proliferation and aberrant differentiation in head and neck squamous cell carcinoma. |
| 260 | _ | _ | |a Bognor Regis [u.a.] |c 2020 |b Wiley |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1577957279_11638 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a 2020 Jan;250(1):107-119 |
| 520 | _ | _ | |a Sustained expression of FOXM1 is a hallmark of nearly all human cancers including squamous cell carcinomas of the head and neck (HNSCC). HNSCCs partially preserve the epithelial differentiation program, which recapitulates fetal and adult traits of the tissue of tumor origin but is deregulated by genetic alterations and tumor-supporting pathways. Using shRNA-induced knockdown, we demonstrate a minimal impact of FOXM1 on proliferation and migration of HNSCC cell lines under standard cell culture conditions. However, FOXM1 knockdown in three-dimensional (3D) culture and xenograft tumor models resulted in reduced proliferation, decreased invasion and a more differentiated-like phenotype, indicating a context dependent modulation of FOXM1 activity in HNSCC cells. By ectopic overexpression of FOXM1 in HNSCC cell lines, we demonstrate a reduced expression of cutaneous-type keratin K1 and involucrin as a marker of squamous differentiation, supporting the role of FOXM1 in modulation of aberrant differentiation in HNSCC. Thus, our data provide a strong rationale for targeting FOXM1 in HNSCC. This article is protected by copyright. All rights reserved. |
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| 700 | 1 | _ | |a Hiou-Feige, Agnès |b 1 |
| 700 | 1 | _ | |a Misetic, Vinko |b 2 |
| 700 | 1 | _ | |a Rivals, Jean-Paul |b 3 |
| 700 | 1 | _ | |a Sponarova, Jana |b 4 |
| 700 | 1 | _ | |a Teh, Muy-Teck |b 5 |
| 700 | 1 | _ | |a Ferreira Lopes, Silvia |b 6 |
| 700 | 1 | _ | |a Truan, Zinnia |b 7 |
| 700 | 1 | _ | |a Mermod, Maxime |b 8 |
| 700 | 1 | _ | |a Monnier, Yan |b 9 |
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| 700 | 1 | _ | |a Tolstonog, Genrich V |0 0000-0002-5560-4157 |b 11 |
| 700 | 1 | _ | |a Simon, Christian |b 12 |
| 773 | _ | _ | |a 10.1002/path.5342 |g p. path.5342 |0 PERI:(DE-600)1475280-3 |n 1 |p 107-119 |t The journal of pathology |v 250 |y 2020 |x 1096-9896 |
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