Journal Article

DKFZ-2019-02140

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The transcription factor FOXM1 regulates the balance between proliferation and aberrant differentiation in head and neck squamous cell carcinoma.

Roh, V. ; Hiou-Feige, A. ; Misetic, V. ; Rivals, J.-P. ; Sponarova, J. ; Teh, M.-T. ; Ferreira Lopes, S. ; Truan, Z. ; Mermod, M. ; Monnier, Y. ; Hess, J.DKFZ* ; Tolstonog, G. V. ; Simon, C.

2020
Wiley Bognor Regis [u.a.]

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Please use a persistent id in citations: doi:10.1002/path.5342

Abstract: Sustained expression of FOXM1 is a hallmark of nearly all human cancers including squamous cell carcinomas of the head and neck (HNSCC). HNSCCs partially preserve the epithelial differentiation program, which recapitulates fetal and adult traits of the tissue of tumor origin but is deregulated by genetic alterations and tumor-supporting pathways. Using shRNA-induced knockdown, we demonstrate a minimal impact of FOXM1 on proliferation and migration of HNSCC cell lines under standard cell culture conditions. However, FOXM1 knockdown in three-dimensional (3D) culture and xenograft tumor models resulted in reduced proliferation, decreased invasion and a more differentiated-like phenotype, indicating a context dependent modulation of FOXM1 activity in HNSCC cells. By ectopic overexpression of FOXM1 in HNSCC cell lines, we demonstrate a reduced expression of cutaneous-type keratin K1 and involucrin as a marker of squamous differentiation, supporting the role of FOXM1 in modulation of aberrant differentiation in HNSCC. Thus, our data provide a strong rationale for targeting FOXM1 in HNSCC. This article is protected by copyright. All rights reserved.

Note: 2020 Jan;250(1):107-119

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Contributing Institute(s):

1. Molekulare Grundlagen von HNO-Tumoren (A102)

Research Program(s):

1. 311 - Signalling pathways, cell and tumor biology (POF3-311) (POF3-311)

Appears in the scientific report 2020

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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