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@ARTICLE{Butt:144762,
      author       = {J. A. Butt$^*$ and M. Jenab and M. Pawlita$^*$ and K.
                      Overvad and A. Tjonneland and A. Olsen and M.-C.
                      Boutron-Ruault and F. Carbonnel and F. R. Mancini and R.
                      Kaaks$^*$ and T. Kühn$^*$ and H. Boeing and A. Trichopoulou
                      and A. Karakatsani and D. Palli and V. M. Pala and R. Tumino
                      and C. Sacerdote and S. Panico and B. Bueno-de-Mesquita and
                      C. H. van Gils and R. C. H. Vermeulen and E. Weiderpass and
                      J. R. Quirós and E. J. Duell and M.-J. Sánchez and M.
                      Dorronsoro and J. M. Huerta and E. Ardanaz and B. Van
                      Guelpen and S. Harlid and A. Perez-Cornago and M. J. Gunter
                      and N. Murphy and H. Freisling and D. Aune and T.
                      Waterboer$^*$ and D. J. Hughes},
      title        = {{A}ntibody {R}esponses to {F}usobacterium nucleatum
                      {P}roteins in {P}rediagnostic {B}lood {S}amples are not
                      {A}ssociated with {R}isk of {D}eveloping {C}olorectal
                      {C}ancer.},
      journal      = {Cancer epidemiology, biomarkers $\&$ prevention},
      volume       = {28},
      number       = {9},
      issn         = {1538-7755},
      address      = {Philadelphia, Pa.},
      publisher    = {AACR},
      reportid     = {DKFZ-2019-02194},
      pages        = {1552 - 1555},
      year         = {2019},
      note         = {#EA:F022#},
      abstract     = {There is a lack of prospective data on the potential
                      association of Fusobacterium nucleatum (F. nucleatum) and
                      colorectal cancer risk. In this study, we assessed whether
                      antibody responses to F. nucleatum are associated with
                      colorectal cancer risk in prediagnostic serum samples in the
                      European Prospective Investigation into Nutrition and Cancer
                      (EPIC) cohort.We applied a multiplex serology assay to
                      simultaneously measure antibody responses to 11 F. nucleatum
                      antigens in prediagnostic serum samples from 485 colorectal
                      cancer cases and 485 matched controls. Conditional logistic
                      regression models were used to estimate odds ratios (ORs)
                      and $95\%$ confidence intervals (CI).We observed neither a
                      statistically significant colorectal cancer risk association
                      for antibodies to individual F. nucleatum proteins nor for
                      combined positivity to any of the 11 proteins (OR, 0.81;
                      $95\%$ CI, 0.62-1.06).Antibody responses to F. nucleatum
                      proteins in prediagnostic serum samples from a subset of
                      colorectal cancer cases and matched controls within the EPIC
                      study were not associated with colorectal cancer risk.Our
                      findings in prospectively ascertained serum samples
                      contradict the existing literature on the association of F.
                      nucleatum with colorectal cancer risk. Future prospective
                      studies, specifically detecting F. nucleatum in stool or
                      tissue biopsies, are needed to complement our findings.},
      cin          = {F022 / F020 / C020},
      ddc          = {610},
      cid          = {I:(DE-He78)F022-20160331 / I:(DE-He78)F020-20160331 /
                      I:(DE-He78)C020-20160331},
      pnm          = {316 - Infections and cancer (POF3-316)},
      pid          = {G:(DE-HGF)POF3-316},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31481495},
      doi          = {10.1158/1055-9965.EPI-19-0313},
      url          = {https://inrepo02.dkfz.de/record/144762},
}