Journal Article

DKFZ-2019-02194

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Antibody Responses to Fusobacterium nucleatum Proteins in Prediagnostic Blood Samples are not Associated with Risk of Developing Colorectal Cancer.

Butt, J. A. (First author)DKFZ* ; Jenab, M. ; Pawlita, M.DKFZ* ; Overvad, K. ; Tjonneland, A. ; Olsen, A. ; Boutron-Ruault, M.-C. ; Carbonnel, F. ; Mancini, F. R. ; Kaaks, R.DKFZ* ; Kühn, T.DKFZ* ; Boeing, H. ; Trichopoulou, A. ; Karakatsani, A. ; Palli, D. ; Pala, V. M. ; Tumino, R. ; Sacerdote, C. ; Panico, S. ; Bueno-de-Mesquita, B. ; van Gils, C. H. ; Vermeulen, R. C. H. ; Weiderpass, E. ; Quirós, J. R. ; Duell, E. J. ; Sánchez, M.-J. ; Dorronsoro, M. ; Huerta, J. M. ; Ardanaz, E. ; Van Guelpen, B. ; Harlid, S. ; Perez-Cornago, A. ; Gunter, M. J. ; Murphy, N. ; Freisling, H. ; Aune, D. ; Waterboer, T. (Last author)DKFZ* ; Hughes, D. J.

2019
AACR Philadelphia, Pa.

This record in other databases:  

Please use a persistent id in citations: doi:10.1158/1055-9965.EPI-19-0313

Abstract: There is a lack of prospective data on the potential association of Fusobacterium nucleatum (F. nucleatum) and colorectal cancer risk. In this study, we assessed whether antibody responses to F. nucleatum are associated with colorectal cancer risk in prediagnostic serum samples in the European Prospective Investigation into Nutrition and Cancer (EPIC) cohort.We applied a multiplex serology assay to simultaneously measure antibody responses to 11 F. nucleatum antigens in prediagnostic serum samples from 485 colorectal cancer cases and 485 matched controls. Conditional logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CI).We observed neither a statistically significant colorectal cancer risk association for antibodies to individual F. nucleatum proteins nor for combined positivity to any of the 11 proteins (OR, 0.81; 95% CI, 0.62-1.06).Antibody responses to F. nucleatum proteins in prediagnostic serum samples from a subset of colorectal cancer cases and matched controls within the EPIC study were not associated with colorectal cancer risk.Our findings in prospectively ascertained serum samples contradict the existing literature on the association of F. nucleatum with colorectal cancer risk. Future prospective studies, specifically detecting F. nucleatum in stool or tissue biopsies, are needed to complement our findings.

Note: #EA:F022#

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Contributing Institute(s):

1. F022 Infektionen und Krebs-Epidemiologie (F022)
2. F020 Molekulare Diagnostik Oncogener Infektionen (F020)
3. C020 Epidemiologie von Krebs (C020)

Research Program(s):

1. 316 - Infections and cancer (POF3-316) (POF3-316)

Appears in the scientific report 2019

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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