TY  - JOUR
AU  - Hekler, Achim
AU  - Utikal, Jochen S
AU  - Enk, Alexander H
AU  - Hauschild, Axel
AU  - Weichenthal, Michael
AU  - Maron, Roman C
AU  - Berking, Carola
AU  - Haferkamp, Sebastian
AU  - Klode, Joachim
AU  - Schadendorf, Dirk
AU  - Schilling, Bastian
AU  - Holland-Letz, Tim
AU  - Izar, Benjamin
AU  - von Kalle, Christof
AU  - Fröhling, Stefan
AU  - Brinker, Titus J
AU  - Schmitt, Laurenz
AU  - Peitsch, Wiebke K
AU  - Hoffmann, Friederike
AU  - Becker, Jürgen C
AU  - Drusio, Christina
AU  - Jansen, Philipp
AU  - Klode, Joachim
AU  - Lodde, Georg
AU  - Sammet, Stefanie
AU  - Schadendorf, Dirk
AU  - Sondermann, Wiebke
AU  - Ugurel, Selma
AU  - Zader, Jeannine
AU  - Enk, Alexander
AU  - Salzmann, Martin
AU  - Schäfer, Sarah
AU  - Schäkel, Knut
AU  - Winkler, Julia
AU  - Wölbing, Priscilla
AU  - Asper, Hiba
AU  - Bohne, Ann-Sophie
AU  - Brown, Victoria
AU  - Burba, Bianca
AU  - Deffaa, Sophia
AU  - Dietrich, Cecilia
AU  - Dietrich, Matthias
AU  - Drerup, Katharina Antonia
AU  - Egberts, Friederike
AU  - Erkens, Anna-Sophie
AU  - Greven, Salim
AU  - Harde, Viola
AU  - Jost, Marion
AU  - Kaeding, Merit
AU  - Kosova, Katharina
AU  - Lischner, Stephan
AU  - Maagk, Maria
AU  - Messinger, Anna Laetitia
AU  - Metzner, Malte
AU  - Motamedi, Rogina
AU  - Rosenthal, Ann-Christine
AU  - Seidl, Ulrich
AU  - Stemmermann, Jana
AU  - Torz, Kaspar
AU  - Velez, Juliana Giraldo
AU  - Haiduk, Jennifer
AU  - Alter, Mareike
AU  - Bär, Claudia
AU  - Bergenthal, Paul
AU  - Gerlach, Anne
AU  - Holtorf, Christian
AU  - Karoglan, Ante
AU  - Kindermann, Sophie
AU  - Kraas, Luise
AU  - Felcht, Moritz
AU  - Gaiser, Maria R
AU  - Klemke, Claus-Detlev
AU  - Kurzen, Hjalmar
AU  - Leibing, Thomas
AU  - Müller, Verena
AU  - Reinhard, Raphael R
AU  - Utikal, Jochen
AU  - Winter, Franziska
AU  - Berking, Carola
AU  - Eicher, Laurie
AU  - Hartmann, Daniela
AU  - Heppt, Markus
AU  - Kilian, Katharina
AU  - Krammer, Sebastian
AU  - Lill, Diana
AU  - Niesert, Anne-Charlotte
AU  - Oppel, Eva
AU  - Sattler, Elke
AU  - Senner, Sonja
AU  - Wallmichrath, Jens
AU  - Wolff, Hans
AU  - Gesierich, Anja
AU  - Giner, Tina
AU  - Glutsch, Valerie
AU  - Kerstan, Andreas
AU  - Presser, Dagmar
AU  - Schrüfer, Philipp
AU  - Schummer, Patrick
AU  - Stolze, Ina
AU  - Weber, Judith
AU  - Drexler, Konstantin
AU  - Haferkamp, Sebastian
AU  - Mickler, Marion
AU  - Stauner, Camila Toledo
AU  - Thiem, Alexander
TI  - Superior skin cancer classification by the combination of human and artificial intelligence.
JO  - European journal of cancer
VL  - 120
SN  - 0959-8049
CY  - Amsterdam [u.a.]
PB  - Elsevier
M1  - DKFZ-2019-02202
SP  - 114 - 121
PY  - 2019
AB  - In recent studies, convolutional neural networks (CNNs) outperformed dermatologists in distinguishing dermoscopic images of melanoma and nevi. In these studies, dermatologists and artificial intelligence were considered as opponents. However, the combination of classifiers frequently yields superior results, both in machine learning and among humans. In this study, we investigated the potential benefit of combining human and artificial intelligence for skin cancer classification.Using 11,444 dermoscopic images, which were divided into five diagnostic categories, novel deep learning techniques were used to train a single CNN. Then, both 112 dermatologists of 13 German university hospitals and the trained CNN independently classified a set of 300 biopsy-verified skin lesions into those five classes. Taking into account the certainty of the decisions, the two independently determined diagnoses were combined to a new classifier with the help of a gradient boosting method. The primary end-point of the study was the correct classification of the images into five designated categories, whereas the secondary end-point was the correct classification of lesions as either benign or malignant (binary classification).Regarding the multiclass task, the combination of man and machine achieved an accuracy of 82.95
LB  - PUB:(DE-HGF)16
C6  - pmid:31518967
DO  - DOI:10.1016/j.ejca.2019.07.019
UR  - https://inrepo02.dkfz.de/record/144770
ER  -