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@ARTICLE{Cervenka:144812,
      author       = {I. Cervenka and M. Al Rahmoun and Y. Mahamat-Saleh and A.
                      Fournier and M. C. Boutron-Ruault and G. Severi and S. Caini
                      and D. Palli and R. Ghiasvand and M. B. Veierod and E.
                      Botteri and A. Tjønneland and A. Olsen and R. T.
                      Fortner$^*$ and R. Kaaks$^*$ and M. B. Schulze and S. Panico
                      and A. Trichopoulou and C. Dessinioti and K. Niforou and S.
                      Sieri and R. Tumino and C. Sacerdote and B.
                      Bueno-de-Mesquita and T. M. Sandanger and S. Colorado-Yohar
                      and M. J. Sánchez and L. Gil Majuelo and L. Lujan-Barroso
                      and E. Ardanaz and S. Merino and K. Isaksson and S. Butt and
                      I. Ljuslinder and M. Jansson and R. C. Travis and K. T. Khaw
                      and E. Weiderpass and L. Dossus and S. Rinaldi and M.
                      Kvaskoff},
      title        = {{E}xogenous {H}ormone {U}se and {C}utaneous {M}elanoma
                      {R}isk in {W}omen: {T}he {E}uropean {P}rospective
                      {I}nvestigation {I}nto {C}ancer and {N}utrition.},
      journal      = {International journal of cancer},
      volume       = {146},
      number       = {12},
      issn         = {1097-0215},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2019-02237},
      pages        = {3267-3280},
      year         = {2020},
      note         = {2020 Jun 15;146(12):3267-3280},
      abstract     = {Evidence suggests an influence of sex hormones on cutaneous
                      melanoma risk, but epidemiologic findings are conflicting.
                      We examined the associations between use of oral
                      contraceptives (OCs) and menopausal hormone therapy (MHT)
                      and melanoma risk in women participating in the European
                      Prospective Investigation into Cancer and Nutrition (EPIC).
                      EPIC is a prospective cohort study initiated in 1992 in 10
                      European countries. Information on exogenous hormone use at
                      baseline was derived from country-specific self-administered
                      questionnaires. We used Cox proportional hazards regression
                      models to calculate hazard ratios (HRs) and $95\%$
                      confidence intervals (CIs). Over 1992-2015, 1,696 melanoma
                      cases were identified among 334,483 women, whereof 770 cases
                      among 134,758 postmenopausal women. There was a positive,
                      borderline-significant association between OC use and
                      melanoma risk (HR=1.12, $95\%$ CI=1.00-1.26), with no
                      detected heterogeneity across countries (Phomogeneity
                      =0.42). This risk increased linearly with duration of use
                      (Ptrend =0.01). Among postmenopausal women, ever use of MHT
                      was associated with a non-significant increase in melanoma
                      risk overall (HR=1.14, $95\%$ CI=0.97-1.43), which was
                      heterogeneous across countries (Phomogeneity =0.05). Our
                      findings do not support a strong and direct association
                      between exogenous hormone use and melanoma risk. In order to
                      better understand these relations, further research should
                      be performed using prospectively collected data including
                      detailed information on types of hormone, and on sun
                      exposure, which may act as an important confounder or effect
                      modifier on these relations. This article is protected by
                      copyright. All rights reserved.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31506954},
      doi          = {10.1002/ijc.32674},
      url          = {https://inrepo02.dkfz.de/record/144812},
}