Journal Article

DKFZ-2019-02237

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Exogenous Hormone Use and Cutaneous Melanoma Risk in Women: The European Prospective Investigation Into Cancer and Nutrition.

Cervenka, I. ; Al Rahmoun, M. ; Mahamat-Saleh, Y. ; Fournier, A. ; Boutron-Ruault, M. C. ; Severi, G. ; Caini, S. ; Palli, D. ; Ghiasvand, R. ; Veierod, M. B. ; Botteri, E. ; Tjønneland, A. ; Olsen, A. ; Fortner, R. T.DKFZ* ; Kaaks, R.DKFZ* ; Schulze, M. B. ; Panico, S. ; Trichopoulou, A. ; Dessinioti, C. ; Niforou, K. ; Sieri, S. ; Tumino, R. ; Sacerdote, C. ; Bueno-de-Mesquita, B. ; Sandanger, T. M. ; Colorado-Yohar, S. ; Sánchez, M. J. ; Gil Majuelo, L. ; Lujan-Barroso, L. ; Ardanaz, E. ; Merino, S. ; Isaksson, K. ; Butt, S. ; Ljuslinder, I. ; Jansson, M. ; Travis, R. C. ; Khaw, K. T. ; Weiderpass, E. ; Dossus, L. ; Rinaldi, S. ; Kvaskoff, M.

2020
Wiley-Liss Bognor Regis

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Please use a persistent id in citations: doi:10.1002/ijc.32674

Abstract: Evidence suggests an influence of sex hormones on cutaneous melanoma risk, but epidemiologic findings are conflicting. We examined the associations between use of oral contraceptives (OCs) and menopausal hormone therapy (MHT) and melanoma risk in women participating in the European Prospective Investigation into Cancer and Nutrition (EPIC). EPIC is a prospective cohort study initiated in 1992 in 10 European countries. Information on exogenous hormone use at baseline was derived from country-specific self-administered questionnaires. We used Cox proportional hazards regression models to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). Over 1992-2015, 1,696 melanoma cases were identified among 334,483 women, whereof 770 cases among 134,758 postmenopausal women. There was a positive, borderline-significant association between OC use and melanoma risk (HR=1.12, 95% CI=1.00-1.26), with no detected heterogeneity across countries (Phomogeneity =0.42). This risk increased linearly with duration of use (Ptrend =0.01). Among postmenopausal women, ever use of MHT was associated with a non-significant increase in melanoma risk overall (HR=1.14, 95% CI=0.97-1.43), which was heterogeneous across countries (Phomogeneity =0.05). Our findings do not support a strong and direct association between exogenous hormone use and melanoma risk. In order to better understand these relations, further research should be performed using prospectively collected data including detailed information on types of hormone, and on sun exposure, which may act as an important confounder or effect modifier on these relations. This article is protected by copyright. All rights reserved.

Note: 2020 Jun 15;146(12):3267-3280

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Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)

Research Program(s):

1. 312 - Functional and structural genomics (POF3-312) (POF3-312)

Appears in the scientific report 2020

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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