%0 Journal Article
%A O'Connor, Tracy
%A Zhou, Xiaolan
%A Kosla, Jan
%A Adili, Arlind
%A Garcia Beccaria, Maria
%A Kotsiliti, Elena
%A Pfister, Dominik
%A Johlke, Anna-Lena
%A Sinha, Ankit
%A Sankowski, Roman
%A Schick, Markus
%A Lewis, Richard
%A Dokalis, Nikolaos
%A Seubert, Bastian
%A Höchst, Bastian
%A Inverso, Donato
%A Heide, Danijela
%A Zhang, Wenlong
%A Weihrich, Petra
%A Manske, Katrin
%A Wohlleber, Dirk
%A Anton, Martina
%A Hoellein, Alexander
%A Seleznik, Gitta
%A Bremer, Juliane
%A Bleul, Sabine
%A Augustin, Hellmut G
%A Scherer, Florian
%A Koedel, Uwe
%A Weber, Achim
%A Protzer, Ulrike
%A Förster, Reinhold
%A Wirth, Thomas
%A Aguzzi, Adriano
%A Meissner, Felix
%A Prinz, Marco
%A Baumann, Bernd
%A Höpken, Uta E
%A Knolle, Percy A
%A von Baumgarten, Louisa
%A Keller, Ulrich
%A Heikenwälder, Mathias
%T Age-Related Gliosis Promotes Central Nervous System Lymphoma through CCL19-Mediated Tumor Cell Retention.
%J Cancer cell
%V 36
%N 3
%@ 1535-6108
%C New York, NY
%I Elsevier
%M DKFZ-2019-02268
%P 250 - 267.e9
%D 2019
%Z DKFZ-ZMBH Alliance
%X How lymphoma cells (LCs) invade the brain during the development of central nervous system lymphoma (CNSL) is unclear. We found that NF-κB-induced gliosis promotes CNSL in immunocompetent mice. Gliosis elevated cell-adhesion molecules, which increased LCs in the brain but was insufficient to induce CNSL. Astrocyte-derived CCL19 was required for gliosis-induced CNSL. Deleting CCL19 in mice or CCR7 from LCs abrogated CNSL development. Two-photon microscopy revealed LCs transiently entering normal brain parenchyma. Astrocytic CCL19 enhanced parenchymal CNS retention of LCs, thereby promoting CNSL formation. Aged, gliotic wild-type mice were more susceptible to forming CNSL than young wild-type mice, and astrocytic CCL19 was observed in both human gliosis and CNSL. Therefore, CCL19-CCR7 interactions may underlie an increased age-related risk for CNSL.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:31526758
%R 10.1016/j.ccell.2019.08.001
%U https://inrepo02.dkfz.de/record/144843