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000144843 1001_ $$0P:(DE-HGF)0$$aO'Connor, Tracy$$b0$$eFirst author
000144843 245__ $$aAge-Related Gliosis Promotes Central Nervous System Lymphoma through CCL19-Mediated Tumor Cell Retention.
000144843 260__ $$aNew York, NY$$bElsevier$$c2019
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000144843 520__ $$aHow lymphoma cells (LCs) invade the brain during the development of central nervous system lymphoma (CNSL) is unclear. We found that NF-κB-induced gliosis promotes CNSL in immunocompetent mice. Gliosis elevated cell-adhesion molecules, which increased LCs in the brain but was insufficient to induce CNSL. Astrocyte-derived CCL19 was required for gliosis-induced CNSL. Deleting CCL19 in mice or CCR7 from LCs abrogated CNSL development. Two-photon microscopy revealed LCs transiently entering normal brain parenchyma. Astrocytic CCL19 enhanced parenchymal CNS retention of LCs, thereby promoting CNSL formation. Aged, gliotic wild-type mice were more susceptible to forming CNSL than young wild-type mice, and astrocytic CCL19 was observed in both human gliosis and CNSL. Therefore, CCL19-CCR7 interactions may underlie an increased age-related risk for CNSL.
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000144843 7001_ $$aZhou, Xiaolan$$b1
000144843 7001_ $$0P:(DE-He78)33b934913c8f151747add87b9420db4c$$aKosla, Jan$$b2$$udkfz
000144843 7001_ $$aAdili, Arlind$$b3
000144843 7001_ $$0P:(DE-HGF)0$$aGarcia Beccaria, Maria$$b4
000144843 7001_ $$0P:(DE-HGF)0$$aKotsiliti, Elena$$b5
000144843 7001_ $$0P:(DE-He78)bbf66dc6580ea5b6a0397bca8bb268d4$$aPfister, Dominik$$b6$$udkfz
000144843 7001_ $$aJohlke, Anna-Lena$$b7
000144843 7001_ $$aSinha, Ankit$$b8
000144843 7001_ $$aSankowski, Roman$$b9
000144843 7001_ $$aSchick, Markus$$b10
000144843 7001_ $$aLewis, Richard$$b11
000144843 7001_ $$aDokalis, Nikolaos$$b12
000144843 7001_ $$aSeubert, Bastian$$b13
000144843 7001_ $$aHöchst, Bastian$$b14
000144843 7001_ $$0P:(DE-He78)a2d0ba20ff9bcfeccbdab04513fbf8f0$$aInverso, Donato$$b15$$udkfz
000144843 7001_ $$0P:(DE-He78)92c93319837b4b915db8393795faf0b6$$aHeide, Danijela$$b16$$udkfz
000144843 7001_ $$aZhang, Wenlong$$b17
000144843 7001_ $$aWeihrich, Petra$$b18
000144843 7001_ $$aManske, Katrin$$b19
000144843 7001_ $$aWohlleber, Dirk$$b20
000144843 7001_ $$aAnton, Martina$$b21
000144843 7001_ $$aHoellein, Alexander$$b22
000144843 7001_ $$aSeleznik, Gitta$$b23
000144843 7001_ $$aBremer, Juliane$$b24
000144843 7001_ $$aBleul, Sabine$$b25
000144843 7001_ $$0P:(DE-He78)2e92d0ae281932fc7347d819fec36b0b$$aAugustin, Hellmut G$$b26$$udkfz
000144843 7001_ $$aScherer, Florian$$b27
000144843 7001_ $$aKoedel, Uwe$$b28
000144843 7001_ $$aWeber, Achim$$b29
000144843 7001_ $$aProtzer, Ulrike$$b30
000144843 7001_ $$aFörster, Reinhold$$b31
000144843 7001_ $$aWirth, Thomas$$b32
000144843 7001_ $$aAguzzi, Adriano$$b33
000144843 7001_ $$aMeissner, Felix$$b34
000144843 7001_ $$aPrinz, Marco$$b35
000144843 7001_ $$aBaumann, Bernd$$b36
000144843 7001_ $$aHöpken, Uta E$$b37
000144843 7001_ $$aKnolle, Percy A$$b38
000144843 7001_ $$avon Baumgarten, Louisa$$b39
000144843 7001_ $$aKeller, Ulrich$$b40
000144843 7001_ $$0P:(DE-He78)66ed2d4ec9bc11d29b87ac006adf85e5$$aHeikenwälder, Mathias$$b41$$eLast author$$udkfz
000144843 773__ $$0PERI:(DE-600)2074034-7$$a10.1016/j.ccell.2019.08.001$$gVol. 36, no. 3, p. 250 - 267.e9$$n3$$p250 - 267.e9$$tCancer cell$$v36$$x1535-6108$$y2019
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