TY  - JOUR
AU  - O'Connor, Tracy
AU  - Zhou, Xiaolan
AU  - Kosla, Jan
AU  - Adili, Arlind
AU  - Garcia Beccaria, Maria
AU  - Kotsiliti, Elena
AU  - Pfister, Dominik
AU  - Johlke, Anna-Lena
AU  - Sinha, Ankit
AU  - Sankowski, Roman
AU  - Schick, Markus
AU  - Lewis, Richard
AU  - Dokalis, Nikolaos
AU  - Seubert, Bastian
AU  - Höchst, Bastian
AU  - Inverso, Donato
AU  - Heide, Danijela
AU  - Zhang, Wenlong
AU  - Weihrich, Petra
AU  - Manske, Katrin
AU  - Wohlleber, Dirk
AU  - Anton, Martina
AU  - Hoellein, Alexander
AU  - Seleznik, Gitta
AU  - Bremer, Juliane
AU  - Bleul, Sabine
AU  - Augustin, Hellmut G
AU  - Scherer, Florian
AU  - Koedel, Uwe
AU  - Weber, Achim
AU  - Protzer, Ulrike
AU  - Förster, Reinhold
AU  - Wirth, Thomas
AU  - Aguzzi, Adriano
AU  - Meissner, Felix
AU  - Prinz, Marco
AU  - Baumann, Bernd
AU  - Höpken, Uta E
AU  - Knolle, Percy A
AU  - von Baumgarten, Louisa
AU  - Keller, Ulrich
AU  - Heikenwälder, Mathias
TI  - Age-Related Gliosis Promotes Central Nervous System Lymphoma through CCL19-Mediated Tumor Cell Retention.
JO  - Cancer cell
VL  - 36
IS  - 3
SN  - 1535-6108
CY  - New York, NY
PB  - Elsevier
M1  - DKFZ-2019-02268
SP  - 250 - 267.e9
PY  - 2019
N1  - DKFZ-ZMBH Alliance
AB  - How lymphoma cells (LCs) invade the brain during the development of central nervous system lymphoma (CNSL) is unclear. We found that NF-κB-induced gliosis promotes CNSL in immunocompetent mice. Gliosis elevated cell-adhesion molecules, which increased LCs in the brain but was insufficient to induce CNSL. Astrocyte-derived CCL19 was required for gliosis-induced CNSL. Deleting CCL19 in mice or CCR7 from LCs abrogated CNSL development. Two-photon microscopy revealed LCs transiently entering normal brain parenchyma. Astrocytic CCL19 enhanced parenchymal CNS retention of LCs, thereby promoting CNSL formation. Aged, gliotic wild-type mice were more susceptible to forming CNSL than young wild-type mice, and astrocytic CCL19 was observed in both human gliosis and CNSL. Therefore, CCL19-CCR7 interactions may underlie an increased age-related risk for CNSL.
LB  - PUB:(DE-HGF)16
C6  - pmid:31526758
DO  - DOI:10.1016/j.ccell.2019.08.001
UR  - https://inrepo02.dkfz.de/record/144843
ER  -