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| 001 | 144843 | ||
| 005 | 20240229112639.0 | ||
| 024 | 7 | _ | |a 10.1016/j.ccell.2019.08.001 |2 doi |
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| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a O'Connor, Tracy |0 P:(DE-HGF)0 |b 0 |e First author |
| 245 | _ | _ | |a Age-Related Gliosis Promotes Central Nervous System Lymphoma through CCL19-Mediated Tumor Cell Retention. |
| 260 | _ | _ | |a New York, NY |c 2019 |b Elsevier |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 520 | _ | _ | |a How lymphoma cells (LCs) invade the brain during the development of central nervous system lymphoma (CNSL) is unclear. We found that NF-κB-induced gliosis promotes CNSL in immunocompetent mice. Gliosis elevated cell-adhesion molecules, which increased LCs in the brain but was insufficient to induce CNSL. Astrocyte-derived CCL19 was required for gliosis-induced CNSL. Deleting CCL19 in mice or CCR7 from LCs abrogated CNSL development. Two-photon microscopy revealed LCs transiently entering normal brain parenchyma. Astrocytic CCL19 enhanced parenchymal CNS retention of LCs, thereby promoting CNSL formation. Aged, gliotic wild-type mice were more susceptible to forming CNSL than young wild-type mice, and astrocytic CCL19 was observed in both human gliosis and CNSL. Therefore, CCL19-CCR7 interactions may underlie an increased age-related risk for CNSL. |
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| 700 | 1 | _ | |a Johlke, Anna-Lena |b 7 |
| 700 | 1 | _ | |a Sinha, Ankit |b 8 |
| 700 | 1 | _ | |a Sankowski, Roman |b 9 |
| 700 | 1 | _ | |a Schick, Markus |b 10 |
| 700 | 1 | _ | |a Lewis, Richard |b 11 |
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| 700 | 1 | _ | |a Zhang, Wenlong |b 17 |
| 700 | 1 | _ | |a Weihrich, Petra |b 18 |
| 700 | 1 | _ | |a Manske, Katrin |b 19 |
| 700 | 1 | _ | |a Wohlleber, Dirk |b 20 |
| 700 | 1 | _ | |a Anton, Martina |b 21 |
| 700 | 1 | _ | |a Hoellein, Alexander |b 22 |
| 700 | 1 | _ | |a Seleznik, Gitta |b 23 |
| 700 | 1 | _ | |a Bremer, Juliane |b 24 |
| 700 | 1 | _ | |a Bleul, Sabine |b 25 |
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| 700 | 1 | _ | |a Scherer, Florian |b 27 |
| 700 | 1 | _ | |a Koedel, Uwe |b 28 |
| 700 | 1 | _ | |a Weber, Achim |b 29 |
| 700 | 1 | _ | |a Protzer, Ulrike |b 30 |
| 700 | 1 | _ | |a Förster, Reinhold |b 31 |
| 700 | 1 | _ | |a Wirth, Thomas |b 32 |
| 700 | 1 | _ | |a Aguzzi, Adriano |b 33 |
| 700 | 1 | _ | |a Meissner, Felix |b 34 |
| 700 | 1 | _ | |a Prinz, Marco |b 35 |
| 700 | 1 | _ | |a Baumann, Bernd |b 36 |
| 700 | 1 | _ | |a Höpken, Uta E |b 37 |
| 700 | 1 | _ | |a Knolle, Percy A |b 38 |
| 700 | 1 | _ | |a von Baumgarten, Louisa |b 39 |
| 700 | 1 | _ | |a Keller, Ulrich |b 40 |
| 700 | 1 | _ | |a Heikenwälder, Mathias |0 P:(DE-He78)66ed2d4ec9bc11d29b87ac006adf85e5 |b 41 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1016/j.ccell.2019.08.001 |g Vol. 36, no. 3, p. 250 - 267.e9 |0 PERI:(DE-600)2074034-7 |n 3 |p 250 - 267.e9 |t Cancer cell |v 36 |y 2019 |x 1535-6108 |
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