Journal Article (Editorial)

DKFZ-2019-02424

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Fighting infant infections with myeloid-derived suppressor cells.

Weber, R. (First author)DKFZ* ; Umansky, V. (Last author)DKFZ*

2019
ASCJ Ann Arbor, Mich.

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Please use a persistent id in citations: doi:10.1172/JCI131649

Abstract: Recent work demonstrated a role for myeloid-derived suppressor cells (MDSCs) in the antimicrobial response in newborns, but the signals guiding their differentiation remained unknown. In this issue of the JCI, Liu et al. demonstrate that lactoferrin (LF) converts newborn neutrophils and monocytes to MDSCs via the low-density lipoprotein receptor-related protein-2 (LRP2) receptor and NF-κB activation. Due to their strong antimicrobial activity, adoptive transfer of MDSCs generated by in vitro culture with LF prolonged the survival of newborn mice with necrotizing enterocolitis, a severe pathology in preterm infants. These findings indicate a surprising protective role of MDSCs in newborns and demonstrate the potential of MDSC therapy for the treatment of infants with diseases associated with deregulated inflammation.

Note: #DKFZ-MOST-Ca181#

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Contributing Institute(s):

1. KKE Dermatoonkologie (A370)

Research Program(s):

1. 311 - Signalling pathways, cell and tumor biology (POF3-311) (POF3-311)

Appears in the scientific report 2019

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 10 ; JCR ; NCBI Molecular Biology Database ; PubMed Central ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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