Journal Article (Review Article)

DKFZ-2019-02493

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Re-irradiation with protons or heavy ions with focus on head and neck, skull base and brain malignancies.

Seidensaal, K. ; Harrabi, S. B. ; Uhl, M. ; Debus, J. (Last author)DKFZ*

2020
Inst. London

This record in other databases:  

Please use a persistent id in citations: doi:10.1259/bjr.20190516

Abstract: Re-irradiation can offer a potentially curative solution in case of progression after initial therapy, however a second course of radiotherapy can be associated with an increased risk of severe side-effects. Particle therapy with protons and especially carbon ions spares surrounding tissue better than most photon techniques, thus it is of high potential for re-irradiation. Irradiation of tumors of the brain, head and neck and skull bases involves several delicate risk organs, e.g. optic system, brainstem, salivary gland or swallowing muscles. Adequate local control rates with tolerable side-effects have been described for several tumors of these locations as meningioma, adenoid cyctic carcinoma, chordoma or chondrosarcoma and head and neck tumors. High life time doses nonetheless lead to a different scope of side-effects, e.g. an enhanced rate of carotid blow outs has been reported. This review summarizes the current data on particle irradiation of the aforementioned locations and malignancies.

Note: 2020 Mar;93(1107):20190516#LA:E050#

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Contributing Institute(s):

1. E050 KKE Strahlentherapie (E050)
2. DKTK HD zentral (HD01)

Research Program(s):

1. 315 - Imaging and radiooncology (POF3-315) (POF3-315)

Appears in the scientific report 2020

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF < 5 ; JCR ; PubMed Central ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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