%0 Journal Article
%A Kliemann, Nathalie
%A Murphy, Neil
%A Viallon, Vivian
%A Freisling, Heinz
%A Tsilidis, Konstantinos K
%A Rinaldi, Sabina
%A Mancini, Francesca Romana
%A Fagherazzi, Guy
%A Boutron-Ruault, Marie-Christine
%A Boeing, Heiner
%A Schulze, Matthias B
%A Masala, Giovanna
%A Krogh, Vittorio
%A Sacerdote, Carlotta
%A Santucci de Magistris, Maria
%A Bueno-de-Mesquita, Bas
%A Weiderpass, Elisabete
%A Kühn, Tilman
%A Kaaks, Rudolf
%A Jakszyn, Paula
%A Redondo-Sánchez, Daniel
%A Amiano, Pilar
%A Chirlaque, Maria-Dolores
%A Barricarte Gurrea, Aurelio
%A Ericson, Ulrica
%A Drake, Isabel
%A Nøst, Therese Haugdahl
%A Aune, Dagfinn
%A May, Anne M
%A Tjønneland, Anne
%A Dahm, Christina Catherine
%A Overvad, Kim
%A Tumino, Rosario
%A Ramón Quirós, Jose
%A Trichopoulou, Antonia
%A Karakatsani, Anna
%A La Vecchia, Carlo
%A Nilsson, Lena Maria
%A Riboli, Elio
%A Huybrechts, Inge
%A Gunter, Marc J
%T Predicted Basal Metabolic Rate and Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (Epic).
%J International journal of cancer
%V 147
%N 3
%@ 1097-0215
%C Bognor Regis
%I Wiley-Liss
%M DKFZ-2019-02506
%P 648-661
%D 2020
%Z 2020 Aug 1;147(3):648-661
%X Emerging evidence suggests that a metabolic profile associated with obesity may be a more relevant risk factor for some cancers than adiposity per se. Basal metabolic rate (BMR) is an indicator of overall body metabolism and may be a proxy for the impact of a specific metabolic profile on cancer risk. Therefore, we investigated the association of estimated BMR with incidence of 13 obesity-related cancers in the European Prospective Investigation into Cancer and Nutrition. Estimated BMR at baseline was calculated using the WHO/FAO/UNU equations and the relationships between BMR and cancer risk were investigated using multivariable Cox proportional hazards regression models. A total of 141,295 men and 317,613 women, with a mean follow-up of 14 years were included in the analysis. Overall, higher BMR was associated with a greater risk for most cancers that have been linked with obesity. However, among normal weight participants, higher BMR was associated with elevated risks of esophageal adenocarcinoma (Hazard Ratio per 1-standard deviation change in BMR [HR1-sd ]: 2.46; 95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:31652358
%R 10.1002/ijc.32753
%U https://inrepo02.dkfz.de/record/147389