Journal Article

DKFZ-2019-02506

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Predicted Basal Metabolic Rate and Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (Epic).

Kliemann, N. ; Murphy, N. ; Viallon, V. ; Freisling, H. ; Tsilidis, K. K. ; Rinaldi, S. ; Mancini, F. R. ; Fagherazzi, G. ; Boutron-Ruault, M.-C. ; Boeing, H. ; Schulze, M. B. ; Masala, G. ; Krogh, V. ; Sacerdote, C. ; Santucci de Magistris, M. ; Bueno-de-Mesquita, B. ; Weiderpass, E. ; Kühn, T.DKFZ* ; Kaaks, R.DKFZ* ; Jakszyn, P. ; Redondo-Sánchez, D. ; Amiano, P. ; Chirlaque, M.-D. ; Barricarte Gurrea, A. ; Ericson, U. ; Drake, I. ; Nøst, T. H. ; Aune, D. ; May, A. M. ; Tjønneland, A. ; Dahm, C. C. ; Overvad, K. ; Tumino, R. ; Ramón Quirós, J. ; Trichopoulou, A. ; Karakatsani, A. ; La Vecchia, C. ; Nilsson, L. M. ; Riboli, E. ; Huybrechts, I. ; Gunter, M. J.

2020
Wiley-Liss Bognor Regis

This record in other databases:  

Please use a persistent id in citations: doi:10.1002/ijc.32753

Abstract: Emerging evidence suggests that a metabolic profile associated with obesity may be a more relevant risk factor for some cancers than adiposity per se. Basal metabolic rate (BMR) is an indicator of overall body metabolism and may be a proxy for the impact of a specific metabolic profile on cancer risk. Therefore, we investigated the association of estimated BMR with incidence of 13 obesity-related cancers in the European Prospective Investigation into Cancer and Nutrition. Estimated BMR at baseline was calculated using the WHO/FAO/UNU equations and the relationships between BMR and cancer risk were investigated using multivariable Cox proportional hazards regression models. A total of 141,295 men and 317,613 women, with a mean follow-up of 14 years were included in the analysis. Overall, higher BMR was associated with a greater risk for most cancers that have been linked with obesity. However, among normal weight participants, higher BMR was associated with elevated risks of esophageal adenocarcinoma (Hazard Ratio per 1-standard deviation change in BMR [HR1-sd ]: 2.46; 95%CI 1.20; 5.03), and distal colon cancer (HR1-sd : 1.33; 95%CI 1.001; 1.77) among men, and with proximal colon (HR1-sd : 1.16; 95%CI 1.01; 1.35), pancreatic (HR1-sd : 1.37; 95%CI 1.13; 1.66), thyroid (HR1-sd : 1.65; 95%CI 1.33; 2.05), postmenopausal breast (HR1-sd : 1.17; 95%CI 1.11; 1.22), and endometrial (HR1-sd : 1.20; 95%CI 1.03; 1.40) cancers in women. These results indicate that higher BMR may be an indicator of a metabolic phenotype associated with risk of certain cancer types, and may be a useful predictor of cancer risk independent of body fatness. This article is protected by copyright. All rights reserved.

Note: 2020 Aug 1;147(3):648-661

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Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)

Research Program(s):

1. 313 - Cancer risk factors and prevention (POF3-313) (POF3-313)

Appears in the scientific report 2020

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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