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000147389 1001_ $$00000-0002-1778-9998$$aKliemann, Nathalie$$b0
000147389 245__ $$aPredicted Basal Metabolic Rate and Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (Epic).
000147389 260__ $$aBognor Regis$$bWiley-Liss$$c2020
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000147389 500__ $$a2020 Aug 1;147(3):648-661
000147389 520__ $$aEmerging evidence suggests that a metabolic profile associated with obesity may be a more relevant risk factor for some cancers than adiposity per se. Basal metabolic rate (BMR) is an indicator of overall body metabolism and may be a proxy for the impact of a specific metabolic profile on cancer risk. Therefore, we investigated the association of estimated BMR with incidence of 13 obesity-related cancers in the European Prospective Investigation into Cancer and Nutrition. Estimated BMR at baseline was calculated using the WHO/FAO/UNU equations and the relationships between BMR and cancer risk were investigated using multivariable Cox proportional hazards regression models. A total of 141,295 men and 317,613 women, with a mean follow-up of 14 years were included in the analysis. Overall, higher BMR was associated with a greater risk for most cancers that have been linked with obesity. However, among normal weight participants, higher BMR was associated with elevated risks of esophageal adenocarcinoma (Hazard Ratio per 1-standard deviation change in BMR [HR1-sd ]: 2.46; 95%CI 1.20; 5.03), and distal colon cancer (HR1-sd : 1.33; 95%CI 1.001; 1.77) among men, and with proximal colon (HR1-sd : 1.16; 95%CI 1.01; 1.35), pancreatic (HR1-sd : 1.37; 95%CI 1.13; 1.66), thyroid (HR1-sd : 1.65; 95%CI 1.33; 2.05), postmenopausal breast (HR1-sd : 1.17; 95%CI 1.11; 1.22), and endometrial (HR1-sd : 1.20; 95%CI 1.03; 1.40) cancers in women. These results indicate that higher BMR may be an indicator of a metabolic phenotype associated with risk of certain cancer types, and may be a useful predictor of cancer risk independent of body fatness. This article is protected by copyright. All rights reserved.
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000147389 7001_ $$00000-0003-3347-8249$$aMurphy, Neil$$b1
000147389 7001_ $$aViallon, Vivian$$b2
000147389 7001_ $$aFreisling, Heinz$$b3
000147389 7001_ $$aTsilidis, Konstantinos K$$b4
000147389 7001_ $$00000-0002-6846-1204$$aRinaldi, Sabina$$b5
000147389 7001_ $$00000-0003-2297-3869$$aMancini, Francesca Romana$$b6
000147389 7001_ $$00000-0001-5033-5966$$aFagherazzi, Guy$$b7
000147389 7001_ $$00000-0002-5956-5693$$aBoutron-Ruault, Marie-Christine$$b8
000147389 7001_ $$aBoeing, Heiner$$b9
000147389 7001_ $$aSchulze, Matthias B$$b10
000147389 7001_ $$aMasala, Giovanna$$b11
000147389 7001_ $$00000-0003-0122-8624$$aKrogh, Vittorio$$b12
000147389 7001_ $$00000-0002-8008-5096$$aSacerdote, Carlotta$$b13
000147389 7001_ $$aSantucci de Magistris, Maria$$b14
000147389 7001_ $$aBueno-de-Mesquita, Bas$$b15
000147389 7001_ $$00000-0003-2237-0128$$aWeiderpass, Elisabete$$b16
000147389 7001_ $$0P:(DE-He78)0907a10ba1dc8f53f04907f54f6fdcfe$$aKühn, Tilman$$b17$$udkfz
000147389 7001_ $$0P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aKaaks, Rudolf$$b18$$udkfz
000147389 7001_ $$00000-0003-0672-8847$$aJakszyn, Paula$$b19
000147389 7001_ $$aRedondo-Sánchez, Daniel$$b20
000147389 7001_ $$aAmiano, Pilar$$b21
000147389 7001_ $$aChirlaque, Maria-Dolores$$b22
000147389 7001_ $$aBarricarte Gurrea, Aurelio$$b23
000147389 7001_ $$aEricson, Ulrica$$b24
000147389 7001_ $$00000-0002-6500-6310$$aDrake, Isabel$$b25
000147389 7001_ $$aNøst, Therese Haugdahl$$b26
000147389 7001_ $$aAune, Dagfinn$$b27
000147389 7001_ $$aMay, Anne M$$b28
000147389 7001_ $$aTjønneland, Anne$$b29
000147389 7001_ $$aDahm, Christina Catherine$$b30
000147389 7001_ $$aOvervad, Kim$$b31
000147389 7001_ $$aTumino, Rosario$$b32
000147389 7001_ $$aRamón Quirós, Jose$$b33
000147389 7001_ $$aTrichopoulou, Antonia$$b34
000147389 7001_ $$aKarakatsani, Anna$$b35
000147389 7001_ $$00000-0003-1441-897X$$aLa Vecchia, Carlo$$b36
000147389 7001_ $$aNilsson, Lena Maria$$b37
000147389 7001_ $$aRiboli, Elio$$b38
000147389 7001_ $$aHuybrechts, Inge$$b39
000147389 7001_ $$aGunter, Marc J$$b40
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