TY  - JOUR
AU  - Kliemann, Nathalie
AU  - Murphy, Neil
AU  - Viallon, Vivian
AU  - Freisling, Heinz
AU  - Tsilidis, Konstantinos K
AU  - Rinaldi, Sabina
AU  - Mancini, Francesca Romana
AU  - Fagherazzi, Guy
AU  - Boutron-Ruault, Marie-Christine
AU  - Boeing, Heiner
AU  - Schulze, Matthias B
AU  - Masala, Giovanna
AU  - Krogh, Vittorio
AU  - Sacerdote, Carlotta
AU  - Santucci de Magistris, Maria
AU  - Bueno-de-Mesquita, Bas
AU  - Weiderpass, Elisabete
AU  - Kühn, Tilman
AU  - Kaaks, Rudolf
AU  - Jakszyn, Paula
AU  - Redondo-Sánchez, Daniel
AU  - Amiano, Pilar
AU  - Chirlaque, Maria-Dolores
AU  - Barricarte Gurrea, Aurelio
AU  - Ericson, Ulrica
AU  - Drake, Isabel
AU  - Nøst, Therese Haugdahl
AU  - Aune, Dagfinn
AU  - May, Anne M
AU  - Tjønneland, Anne
AU  - Dahm, Christina Catherine
AU  - Overvad, Kim
AU  - Tumino, Rosario
AU  - Ramón Quirós, Jose
AU  - Trichopoulou, Antonia
AU  - Karakatsani, Anna
AU  - La Vecchia, Carlo
AU  - Nilsson, Lena Maria
AU  - Riboli, Elio
AU  - Huybrechts, Inge
AU  - Gunter, Marc J
TI  - Predicted Basal Metabolic Rate and Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (Epic).
JO  - International journal of cancer
VL  - 147
IS  - 3
SN  - 1097-0215
CY  - Bognor Regis
PB  - Wiley-Liss
M1  - DKFZ-2019-02506
SP  - 648-661
PY  - 2020
N1  - 2020 Aug 1;147(3):648-661
AB  - Emerging evidence suggests that a metabolic profile associated with obesity may be a more relevant risk factor for some cancers than adiposity per se. Basal metabolic rate (BMR) is an indicator of overall body metabolism and may be a proxy for the impact of a specific metabolic profile on cancer risk. Therefore, we investigated the association of estimated BMR with incidence of 13 obesity-related cancers in the European Prospective Investigation into Cancer and Nutrition. Estimated BMR at baseline was calculated using the WHO/FAO/UNU equations and the relationships between BMR and cancer risk were investigated using multivariable Cox proportional hazards regression models. A total of 141,295 men and 317,613 women, with a mean follow-up of 14 years were included in the analysis. Overall, higher BMR was associated with a greater risk for most cancers that have been linked with obesity. However, among normal weight participants, higher BMR was associated with elevated risks of esophageal adenocarcinoma (Hazard Ratio per 1-standard deviation change in BMR [HR1-sd ]: 2.46; 95
LB  - PUB:(DE-HGF)16
C6  - pmid:31652358
DO  - DOI:10.1002/ijc.32753
UR  - https://inrepo02.dkfz.de/record/147389
ER  -