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      author       = {N. Kliemann and N. Murphy and V. Viallon and H. Freisling
                      and K. K. Tsilidis and S. Rinaldi and F. R. Mancini and G.
                      Fagherazzi and M.-C. Boutron-Ruault and H. Boeing and M. B.
                      Schulze and G. Masala and V. Krogh and C. Sacerdote and M.
                      Santucci de Magistris and B. Bueno-de-Mesquita and E.
                      Weiderpass and T. Kühn$^*$ and R. Kaaks$^*$ and P. Jakszyn
                      and D. Redondo-Sánchez and P. Amiano and M.-D. Chirlaque
                      and A. Barricarte Gurrea and U. Ericson and I. Drake and T.
                      H. Nøst and D. Aune and A. M. May and A. Tjønneland and C.
                      C. Dahm and K. Overvad and R. Tumino and J. Ramón Quirós
                      and A. Trichopoulou and A. Karakatsani and C. La Vecchia and
                      L. M. Nilsson and E. Riboli and I. Huybrechts and M. J.
      title        = {{P}redicted {B}asal {M}etabolic {R}ate and {C}ancer {R}isk
                      in the {E}uropean {P}rospective {I}nvestigation into
                      {C}ancer and {N}utrition ({E}pic).},
      journal      = {International journal of cancer},
      volume       = {147},
      number       = {3},
      issn         = {1097-0215},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2019-02506},
      pages        = {648-661},
      year         = {2020},
      note         = {2020 Aug 1;147(3):648-661},
      abstract     = {Emerging evidence suggests that a metabolic profile
                      associated with obesity may be a more relevant risk factor
                      for some cancers than adiposity per se. Basal metabolic rate
                      (BMR) is an indicator of overall body metabolism and may be
                      a proxy for the impact of a specific metabolic profile on
                      cancer risk. Therefore, we investigated the association of
                      estimated BMR with incidence of 13 obesity-related cancers
                      in the European Prospective Investigation into Cancer and
                      Nutrition. Estimated BMR at baseline was calculated using
                      the WHO/FAO/UNU equations and the relationships between BMR
                      and cancer risk were investigated using multivariable Cox
                      proportional hazards regression models. A total of 141,295
                      men and 317,613 women, with a mean follow-up of 14 years
                      were included in the analysis. Overall, higher BMR was
                      associated with a greater risk for most cancers that have
                      been linked with obesity. However, among normal weight
                      participants, higher BMR was associated with elevated risks
                      of esophageal adenocarcinoma (Hazard Ratio per 1-standard
                      deviation change in BMR [HR1-sd ]: 2.46; $95\%CI$ 1.20;
                      5.03), and distal colon cancer (HR1-sd : 1.33; $95\%CI$
                      1.001; 1.77) among men, and with proximal colon (HR1-sd :
                      1.16; $95\%CI$ 1.01; 1.35), pancreatic (HR1-sd : 1.37;
                      $95\%CI$ 1.13; 1.66), thyroid (HR1-sd : 1.65; $95\%CI$ 1.33;
                      2.05), postmenopausal breast (HR1-sd : 1.17; $95\%CI$ 1.11;
                      1.22), and endometrial (HR1-sd : 1.20; $95\%CI$ 1.03; 1.40)
                      cancers in women. These results indicate that higher BMR may
                      be an indicator of a metabolic phenotype associated with
                      risk of certain cancer types, and may be a useful predictor
                      of cancer risk independent of body fatness. This article is
                      protected by copyright. All rights reserved.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31652358},
      doi          = {10.1002/ijc.32753},
      url          = {https://inrepo02.dkfz.de/record/147389},