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@ARTICLE{Heisser:147628,
      author       = {T. Heisser$^*$ and L. Peng$^*$ and K. Weigl$^*$ and M.
                      Hoffmeister$^*$ and H. Brenner$^*$},
      title        = {{O}utcomes at follow-up of negative colonoscopy in average
                      risk population: systematic review and meta-analysis.},
      journal      = {The BMJ},
      volume       = {367},
      issn         = {0959-8138},
      address      = {London},
      publisher    = {British Medical Association56099},
      reportid     = {DKFZ-2019-02619},
      pages        = {l6109},
      year         = {2019},
      abstract     = {To review and summarise the evidence on the prevalence of
                      colorectal adenomas and cancers at a follow-up screening
                      colonoscopy after negative index colonoscopy, stratified by
                      interval between examinations and by sex.Systematic review
                      and meta-analysis of all available studies.PubMed, Web of
                      Science, and Embase. Two investigators independently
                      extracted characteristics and results of identified studies
                      and performed standardised quality ratings.Studies assessing
                      the outcome of a follow-up colonoscopy among participants at
                      average risk for colorectal cancer with a negative previous
                      colonoscopy (no adenomas).28 studies were identified,
                      including 22 cohort studies, five cross sectional studies,
                      and one case-control study. Findings for an interval between
                      colonoscopies of one to five, five to 10, and more than 10
                      years were reported by 17, 16, and three studies,
                      respectively. Summary estimates of prevalences of any
                      neoplasm were $20.7\%$ $(95\%$ confidence interval $15.8\%$
                      to $25.5\%),$ $23.0\%$ $(18.0\%$ to $28.0\%),$ and $21.9\%$
                      $(14.9\%$ to $29.0\%)$ for one to five, five to 10, and more
                      than 10 years between colonoscopies. Corresponding summary
                      estimates of prevalences of any advanced neoplasm were
                      $2.8\%$ $(2.0\%$ to $3.7\%),$ $3.2\%$ $(2.2\%$ to $4.1\%),$
                      and $7.0\%$ $(5.3\%$ to $8.7\%).$ Seven studies also
                      reported findings stratified by sex. Summary estimates
                      stratified by interval and sex were consistently higher for
                      men than for women.Although detection of any neoplasms was
                      observed in more than $20\%$ of participants within five
                      years of a negative screening colonoscopy, detection of
                      advanced neoplasms within 10 years was rare. Our findings
                      suggest that 10 year intervals for colonoscopy screening
                      after a negative colonoscopy, as currently recommended, may
                      be adequate, but more studies are needed to strengthen the
                      empirical basis for pertinent recommendations and to
                      investigate even longer intervals.Prospero CRD42019127842.},
      subtyp        = {Review Article},
      cin          = {C070 / L101 / C120},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)L101-20160331 /
                      I:(DE-He78)C120-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31722884},
      pmc          = {pmc:PMC6853024},
      doi          = {10.1136/bmj.l6109},
      url          = {https://inrepo02.dkfz.de/record/147628},
}