%0 Journal Article
%A Bleeke, Matthias
%A Johann, Pascal
%A Gröbner, Susanne
%A Alten, Julia
%A Cario, Gunnar
%A Schäfer, Hansjörg
%A Klapper, Wolfram
%A Khoury, Joseph
%A Pfister, Stefan
%A Müller, Ingo
%T Genome-wide analysis of acute leukemia and clonally related histiocytic sarcoma in a series of three pediatric patients.
%J Pediatric blood & cancer
%V 67
%N 2
%@ 1545-5009
%C New York, NY
%I Wiley
%M DKFZ-2019-02645
%P e28074
%D 2020
%Z 2020 Feb;67(2):e28074
%X Pediatric histiocytic sarcoma (HS) clonally related to anteceding leukemia is a rare malignancy with poor outcome. We performed a molecular characterization of HS and the corresponding leukemia by methylation arrays and whole-exome sequencing and found a variety of aberrations in both entities with deletions of CDKN2A/B as a recurrent finding. Furthermore, data from genome-wide mutation analysis from one patient allowed the reconstruction of a sequence of tumorigenesis of leukemia and HS lesions including the acquisition of a putatively activating KRAS frameshift deletion (p.A66fs). Our results provide an insight into the genetic landscape of pediatric HS clonally related to anteceding leukemia.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:31737984
%R 10.1002/pbc.28074
%U https://inrepo02.dkfz.de/record/147654