Journal Article

DKFZ-2019-02645

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Genome-wide analysis of acute leukemia and clonally related histiocytic sarcoma in a series of three pediatric patients.

Bleeke, M. ; Johann, P.DKFZ* ; Gröbner, S.DKFZ* ; Alten, J. ; Cario, G. ; Schäfer, H. ; Klapper, W. ; Khoury, J. ; Pfister, S.DKFZ* ; Müller, I.

2020
Wiley New York, NY

This record in other databases:  

Please use a persistent id in citations: doi:10.1002/pbc.28074

Abstract: Pediatric histiocytic sarcoma (HS) clonally related to anteceding leukemia is a rare malignancy with poor outcome. We performed a molecular characterization of HS and the corresponding leukemia by methylation arrays and whole-exome sequencing and found a variety of aberrations in both entities with deletions of CDKN2A/B as a recurrent finding. Furthermore, data from genome-wide mutation analysis from one patient allowed the reconstruction of a sequence of tumorigenesis of leukemia and HS lesions including the acquisition of a putatively activating KRAS frameshift deletion (p.A66fs). Our results provide an insight into the genetic landscape of pediatric HS clonally related to anteceding leukemia.

Note: 2020 Feb;67(2):e28074

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Contributing Institute(s):

1. Pädiatrische Neuroonkologie (B062)
2. DKTK HD zentral (HD01)

Research Program(s):

1. 312 - Functional and structural genomics (POF3-312) (POF3-312)

Appears in the scientific report 2020

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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