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000147654 1001_ $$00000-0003-0455-8338$$aBleeke, Matthias$$b0
000147654 245__ $$aGenome-wide analysis of acute leukemia and clonally related histiocytic sarcoma in a series of three pediatric patients.
000147654 260__ $$aNew York, NY$$bWiley$$c2020
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000147654 500__ $$a2020 Feb;67(2):e28074
000147654 520__ $$aPediatric histiocytic sarcoma (HS) clonally related to anteceding leukemia is a rare malignancy with poor outcome. We performed a molecular characterization of HS and the corresponding leukemia by methylation arrays and whole-exome sequencing and found a variety of aberrations in both entities with deletions of CDKN2A/B as a recurrent finding. Furthermore, data from genome-wide mutation analysis from one patient allowed the reconstruction of a sequence of tumorigenesis of leukemia and HS lesions including the acquisition of a putatively activating KRAS frameshift deletion (p.A66fs). Our results provide an insight into the genetic landscape of pediatric HS clonally related to anteceding leukemia.
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000147654 7001_ $$0P:(DE-He78)3fdc3623477264cb5d0e14f256dbfbb8$$aJohann, Pascal$$b1$$udkfz
000147654 7001_ $$0P:(DE-He78)932918ed0e8d8790a81235528019a8e0$$aGröbner, Susanne$$b2
000147654 7001_ $$aAlten, Julia$$b3
000147654 7001_ $$00000-0001-8396-0127$$aCario, Gunnar$$b4
000147654 7001_ $$aSchäfer, Hansjörg$$b5
000147654 7001_ $$aKlapper, Wolfram$$b6
000147654 7001_ $$aKhoury, Joseph$$b7
000147654 7001_ $$0P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aPfister, Stefan$$b8$$udkfz
000147654 7001_ $$00000-0002-7477-6632$$aMüller, Ingo$$b9
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