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@ARTICLE{Bleeke:147654,
      author       = {M. Bleeke and P. Johann$^*$ and S. Gröbner$^*$ and J.
                      Alten and G. Cario and H. Schäfer and W. Klapper and J.
                      Khoury and S. Pfister$^*$ and I. Müller},
      title        = {{G}enome-wide analysis of acute leukemia and clonally
                      related histiocytic sarcoma in a series of three pediatric
                      patients.},
      journal      = {Pediatric blood $\&$ cancer},
      volume       = {67},
      number       = {2},
      issn         = {1545-5009},
      address      = {New York, NY},
      publisher    = {Wiley},
      reportid     = {DKFZ-2019-02645},
      pages        = {e28074},
      year         = {2020},
      note         = {2020 Feb;67(2):e28074},
      abstract     = {Pediatric histiocytic sarcoma (HS) clonally related to
                      anteceding leukemia is a rare malignancy with poor outcome.
                      We performed a molecular characterization of HS and the
                      corresponding leukemia by methylation arrays and whole-exome
                      sequencing and found a variety of aberrations in both
                      entities with deletions of CDKN2A/B as a recurrent finding.
                      Furthermore, data from genome-wide mutation analysis from
                      one patient allowed the reconstruction of a sequence of
                      tumorigenesis of leukemia and HS lesions including the
                      acquisition of a putatively activating KRAS frameshift
                      deletion (p.A66fs). Our results provide an insight into the
                      genetic landscape of pediatric HS clonally related to
                      anteceding leukemia.},
      cin          = {B062 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31737984},
      doi          = {10.1002/pbc.28074},
      url          = {https://inrepo02.dkfz.de/record/147654},
}