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| Home > Publications database > Genome-wide analysis of acute leukemia and clonally related histiocytic sarcoma in a series of three pediatric patients. > print |
| 001 | 147654 | ||
| 005 | 20240229123025.0 | ||
| 024 | 7 | _ | |a 10.1002/pbc.28074 |2 doi |
| 024 | 7 | _ | |a pmid:31737984 |2 pmid |
| 024 | 7 | _ | |a 0098-1532 |2 ISSN |
| 024 | 7 | _ | |a 1096-911X |2 ISSN |
| 024 | 7 | _ | |a 1545-5009 |2 ISSN |
| 024 | 7 | _ | |a 1545-5017 |2 ISSN |
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| 037 | _ | _ | |a DKFZ-2019-02645 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Bleeke, Matthias |0 0000-0003-0455-8338 |b 0 |
| 245 | _ | _ | |a Genome-wide analysis of acute leukemia and clonally related histiocytic sarcoma in a series of three pediatric patients. |
| 260 | _ | _ | |a New York, NY |c 2020 |b Wiley |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1580111106_3899 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a 2020 Feb;67(2):e28074 |
| 520 | _ | _ | |a Pediatric histiocytic sarcoma (HS) clonally related to anteceding leukemia is a rare malignancy with poor outcome. We performed a molecular characterization of HS and the corresponding leukemia by methylation arrays and whole-exome sequencing and found a variety of aberrations in both entities with deletions of CDKN2A/B as a recurrent finding. Furthermore, data from genome-wide mutation analysis from one patient allowed the reconstruction of a sequence of tumorigenesis of leukemia and HS lesions including the acquisition of a putatively activating KRAS frameshift deletion (p.A66fs). Our results provide an insight into the genetic landscape of pediatric HS clonally related to anteceding leukemia. |
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| 700 | 1 | _ | |a Johann, Pascal |0 P:(DE-He78)3fdc3623477264cb5d0e14f256dbfbb8 |b 1 |u dkfz |
| 700 | 1 | _ | |a Gröbner, Susanne |0 P:(DE-He78)932918ed0e8d8790a81235528019a8e0 |b 2 |
| 700 | 1 | _ | |a Alten, Julia |b 3 |
| 700 | 1 | _ | |a Cario, Gunnar |0 0000-0001-8396-0127 |b 4 |
| 700 | 1 | _ | |a Schäfer, Hansjörg |b 5 |
| 700 | 1 | _ | |a Klapper, Wolfram |b 6 |
| 700 | 1 | _ | |a Khoury, Joseph |b 7 |
| 700 | 1 | _ | |a Pfister, Stefan |0 P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9 |b 8 |u dkfz |
| 700 | 1 | _ | |a Müller, Ingo |0 0000-0002-7477-6632 |b 9 |
| 773 | _ | _ | |a 10.1002/pbc.28074 |g p. e28074 - |0 PERI:(DE-600)2130978-4 |n 2 |p e28074 |t Pediatric blood & cancer |v 67 |y 2020 |x 1545-5009 |
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