Journal Article

DKFZ-2019-02891

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Rare entities in head-and-neck cancer: salvage re-irradiation with carbon ions.

Held, T. ; Windisch, P. ; Akbaba, S. ; Lang, K. ; Farnia, B. ; Liermann, J. ; Bernhardt, D. ; Plinkert, P. ; Freudlsperger, C. ; Rieken, S. ; Herfarth, K. ; Debus, J.DKFZ* ; Adeberg, S. (Last author)DKFZ*

2019
BioMed Central London

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Please use a persistent id in citations: doi:10.1186/s13014-019-1406-x

Abstract: The objective of this investigation is to evaluate the outcomes and toxicity of carbon-ion re-irradiation (CIR) in patients with rare head and neck cancers (HNC). There is a paucity of data regarding treatment approaches in this patient cohort, which we aim to address in this work.Thirty-two (n = 32) consecutive patients with uncommon HNC treated between 2010 and 2017 were retrospectively analyzed in terms of clinical outcomes, patterns of failure, and toxicity.Mucoepidermoid carcinoma (MEC) was the most common histology (22%). Patients received a median cumulative dose equivalent in 2 Gy fractions (EQD2) after CIR of 128.6 Gy (range, 105.8-146.5 Gy). The local and distant control rates 1 year after CIR were 66 and 72%. No serious acute or late toxicity (≥ grade 3) after CIR was observed.CIR may represent an effective and safe treatment alternative to palliative systemic therapies in these rare indications.

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Contributing Institute(s):

1. KKE Strahlentherapie (E050)
2. DKTK Heidelberg (L101)

Research Program(s):

1. 315 - Imaging and radiooncology (POF3-315) (POF3-315)

Appears in the scientific report 2019

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DOAJ Seal ; Ebsco Academic Search ; NCBI Molecular Biology Database ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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