Journal Article

DKFZ-2019-02917

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Modeling the Effect of Hypoxia and DNA Repair Inhibition on Cell Survival After Photon Irradiation.

Liew, H. (First author)DKFZ* ; Klein, C.DKFZ* ; Zenke, F. T. ; Abdollahi, A.DKFZ* ; Debus, J.DKFZ* ; Dokic, I.DKFZ* ; Mairani, A. (Last author)

2019
Molecular Diversity Preservation International Basel

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Please use a persistent id in citations: doi:10.3390/ijms20236054

Abstract: Mechanistic approaches to modeling the effects of ionizing radiation on cells are on the rise, promising a better understanding of predictions and higher flexibility concerning conditions to be accounted for. In this work we modified and extended a previously published mechanistic model of cell survival after photon irradiation under hypoxia to account for radiosensitization caused by deficiency or inhibition of DNA damage repair enzymes. The model is shown to be capable of describing the survival data of cells with DNA damage repair deficiency, both under norm- and hypoxia. We find that our parameterization of radiosensitization is invariant under change of oxygen status, indicating that the relevant parameters for both mechanisms can be obtained independently and introduced freely to the model to predict their combined effect.

Note: EA:E050LA:E210

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Contributing Institute(s):

1. KKE Strahlentherapie (E050)
2. Translationale Radioonkologie (E210)
3. DKTK Heidelberg (L101)

Research Program(s):

1. 315 - Imaging and radiooncology (POF3-315) (POF3-315)

Appears in the scientific report 2019

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Physical, Chemical and Earth Sciences ; DOAJ Seal ; Ebsco Academic Search ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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