TY  - JOUR
AU  - Snaebjornsson, Marteinn Thor
AU  - Janaki-Raman, Sudha
AU  - Schulze, Almut
TI  - Greasing the Wheels of the Cancer Machine: The Role of Lipid Metabolism in Cancer
JO  - Cell metabolism
VL  - 31
IS  - 1
SN  - 1550-4131
CY  - Cambridge, Mass.
PB  - Cell Press
M1  - DKFZ-2019-02950
SP  - 62-76
PY  - 2020
N1  - PMID: 31813823Grants:FOR2314, SCHU2670/1bei Fragen bitte Anna Lück kontaktieren#EA:A410#LA:A410#2020 Jan 7;31(1):62-76
AB  - Altered lipid metabolism is among the most prominent metabolic alterations in cancer. Enhanced synthesis or uptake of lipids contributes to rapid cancer cell growth and tumor formation. Lipids are a highly complex group of biomolecules that not only constitute the structural basis of biological membranes but also function as signaling molecules and an energy source. Here, we summarize recent evidence implicating altered lipid metabolism in different aspects of the cancer phenotype and discuss potential strategies by which targeting lipid metabolism could provide a therapeutic window for cancer treatment.
LB  - PUB:(DE-HGF)16
C6  - pmid:31813823
DO  - DOI:10.1016/j.cmet.2019.11.010
UR  - https://inrepo02.dkfz.de/record/148395
ER  -