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| Home > Publications database > The role of translationally controlled tumor protein in proliferation of Drosophila intestinal stem cells. |
| Home > Publications database > The role of translationally controlled tumor protein in proliferation of Drosophila intestinal stem cells. |
| Journal Article | DKFZ-2019-03239 |
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2019
National Acad. of Sciences
Washington, DC
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Please use a persistent id in citations: doi:10.1073/pnas.1910850116
Abstract: Translationally controlled tumor protein (TCTP) is a highly conserved protein functioning in multiple cellular processes, ranging from growth to immune responses. To explore the role of TCTP in tissue maintenance and regeneration, we employed the adult Drosophila midgut, where multiple signaling pathways interact to precisely regulate stem cell division for tissue homeostasis. Tctp levels were significantly increased in stem cells and enteroblasts upon tissue damage or activation of the Hippo pathway that promotes regeneration of intestinal epithelium. Stem cells with reduced Tctp levels failed to proliferate during normal tissue homeostasis and regeneration. Mechanistically, Tctp forms a complex with multiple proteins involved in translation and genetically interacts with ribosomal subunits. In addition, Tctp increases both Akt1 protein abundance and phosphorylation in vivo. Altogether, Tctp regulates stem cell proliferation by interacting with key growth regulatory signaling pathways and the translation process in vivo.
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