%0 Journal Article
%A Wang, Xiaoliang
%A O'Connell, Kelli
%A Jeon, Jihyoun
%A Song, Mingyang
%A Hunter, David
%A Hoffmeister, Michael
%A Lin, Yi
%A Berndt, Sonja
%A Brenner, Hermann
%A Chan, Andrew T
%A Chang-Claude, Jenny
%A Gong, Jian
%A Gunter, Marc J
%A Harrison, Tabitha A
%A Hayes, Richard B
%A Joshi, Amit
%A Newcomb, Polly
%A Schoen, Robert
%A Slattery, Martha L
%A Vargas, Ashley
%A Potter, John D
%A Le Marchand, Loic
%A Giovannucci, Edward
%A White, Emily
%A Hsu, Li
%A Peters, Ulrike
%A Du, Mengmeng
%T Combined effect of modifiable and non-modifiable risk factors for colorectal cancer risk in a pooled analysis of 11 population-based studies.
%J BMJ open gastroenterology
%V 6
%N 1
%@ 2054-4774
%C London
%I BMJ Publishing Group
%M DKFZ-2020-00024
%P e000339
%D 2019
%X 'Environmental' factors associated with colorectal cancer (CRC) risk include modifiable and non-modifiable variables. Whether those with different non-modifiable baseline risks will benefit similarly from reducing their modifiable CRC risks remains unclear.Using 7945 cases and 8893 controls from 11 population-based studies, we combined 17 risk factors to characterise the overall environmental predisposition to CRC (environmental risk score (E-score)). We estimated the absolute risks (ARs) of CRC of 10 and 30 years across E-score using incidence-rate data from the Surveillance, Epidemiology, and End Results programme. We then combined the modifiable risk factors and estimated ARs across the modifiable risk score, stratified by non-modifiable risk profile based on genetic predisposition, family history and height.Higher E-score was associated with increased CRC risk (ORquartile, 1.33; 95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:31875139
%2 pmc:PMC6904202
%R 10.1136/bmjgast-2019-000339
%U https://inrepo02.dkfz.de/record/148832