Journal Article

DKFZ-2020-00024

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Combined effect of modifiable and non-modifiable risk factors for colorectal cancer risk in a pooled analysis of 11 population-based studies.

Wang, X. ; O'Connell, K. ; Jeon, J. ; Song, M. ; Hunter, D. ; Hoffmeister, M.DKFZ* ; Lin, Y. ; Berndt, S. ; Brenner, H.DKFZ* ; Chan, A. T. ; Chang-Claude, J.DKFZ* ; Gong, J. ; Gunter, M. J. ; Harrison, T. A. ; Hayes, R. B. ; Joshi, A. ; Newcomb, P. ; Schoen, R. ; Slattery, M. L. ; Vargas, A. ; Potter, J. D. ; Le Marchand, L. ; Giovannucci, E. ; White, E. ; Hsu, L. ; Peters, U. ; Du, M.

2019
BMJ Publishing Group London

This record in other databases:  

Please use a persistent id in citations: doi:10.1136/bmjgast-2019-000339

Abstract: 'Environmental' factors associated with colorectal cancer (CRC) risk include modifiable and non-modifiable variables. Whether those with different non-modifiable baseline risks will benefit similarly from reducing their modifiable CRC risks remains unclear.Using 7945 cases and 8893 controls from 11 population-based studies, we combined 17 risk factors to characterise the overall environmental predisposition to CRC (environmental risk score (E-score)). We estimated the absolute risks (ARs) of CRC of 10 and 30 years across E-score using incidence-rate data from the Surveillance, Epidemiology, and End Results programme. We then combined the modifiable risk factors and estimated ARs across the modifiable risk score, stratified by non-modifiable risk profile based on genetic predisposition, family history and height.Higher E-score was associated with increased CRC risk (ORquartile, 1.33; 95% CI 1.30 to 1.37). Across E-scores, 30-year ARs of CRC increased from 2.5% in the lowest quartile (Q1) to 5.9% in the highest (Q4) quartile for men, and from 2.1% to 4.5% for women. The modifiable risk score had a stronger association in those with high non-modifiable risk (relative excess risk due to interaction=1.2, 95% CI 0.5 to 1.9). For those in Q4 of non-modifiable risk, a decrease in modifiable risk reduced 30-year ARs from 8.9% to 3.4% for men and from 6.0% to 3.2% for women, a level lower or comparable to the average population risk.Changes in modifiable risk factors may result in a substantial decline in CRC risk in both sexes. Those with high inherited risk may reap greater benefit from lifestyle modifications. Our results suggested comprehensive evaluation of environmental factors may facilitate CRC risk stratification.

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Contributing Institute(s):

1. C070 Klinische Epidemiologie und Alternf. (C070)
2. C020 Epidemiologie von Krebs (C020)

Research Program(s):

1. 313 - Cancer risk factors and prevention (POF3-313) (POF3-313)

Appears in the scientific report 2019

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; DOAJ Seal ; Emerging Sources Citation Index ; PubMed Central ; SCOPUS ; Web of Science Core Collection

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