TY  - JOUR
AU  - Wang, Xiaoliang
AU  - O'Connell, Kelli
AU  - Jeon, Jihyoun
AU  - Song, Mingyang
AU  - Hunter, David
AU  - Hoffmeister, Michael
AU  - Lin, Yi
AU  - Berndt, Sonja
AU  - Brenner, Hermann
AU  - Chan, Andrew T
AU  - Chang-Claude, Jenny
AU  - Gong, Jian
AU  - Gunter, Marc J
AU  - Harrison, Tabitha A
AU  - Hayes, Richard B
AU  - Joshi, Amit
AU  - Newcomb, Polly
AU  - Schoen, Robert
AU  - Slattery, Martha L
AU  - Vargas, Ashley
AU  - Potter, John D
AU  - Le Marchand, Loic
AU  - Giovannucci, Edward
AU  - White, Emily
AU  - Hsu, Li
AU  - Peters, Ulrike
AU  - Du, Mengmeng
TI  - Combined effect of modifiable and non-modifiable risk factors for colorectal cancer risk in a pooled analysis of 11 population-based studies.
JO  - BMJ open gastroenterology
VL  - 6
IS  - 1
SN  - 2054-4774
CY  - London
PB  - BMJ Publishing Group
M1  - DKFZ-2020-00024
SP  - e000339
PY  - 2019
AB  - 'Environmental' factors associated with colorectal cancer (CRC) risk include modifiable and non-modifiable variables. Whether those with different non-modifiable baseline risks will benefit similarly from reducing their modifiable CRC risks remains unclear.Using 7945 cases and 8893 controls from 11 population-based studies, we combined 17 risk factors to characterise the overall environmental predisposition to CRC (environmental risk score (E-score)). We estimated the absolute risks (ARs) of CRC of 10 and 30 years across E-score using incidence-rate data from the Surveillance, Epidemiology, and End Results programme. We then combined the modifiable risk factors and estimated ARs across the modifiable risk score, stratified by non-modifiable risk profile based on genetic predisposition, family history and height.Higher E-score was associated with increased CRC risk (ORquartile, 1.33; 95
LB  - PUB:(DE-HGF)16
C6  - pmid:31875139
C2  - pmc:PMC6904202
DO  - DOI:10.1136/bmjgast-2019-000339
UR  - https://inrepo02.dkfz.de/record/148832
ER  -