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000153096 1001_ $$0P:(DE-He78)a4340add02b610f9dbdba2dc909cbd09$$aDelacher, Michael$$b0$$eFirst author
000153096 245__ $$aPrecursors for Nonlymphoid-Tissue Treg Cells Reside in Secondary Lymphoid Organs and Are Programmed by the Transcription Factor BATF.
000153096 260__ $$aNew York, NY$$bElsevier$$c2020
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000153096 520__ $$aSpecialized regulatory T (Treg) cells accumulate and perform homeostatic and regenerative functions in nonlymphoid tissues. Whether common precursors for nonlymphoid-tissue Treg cells exist and how they differentiate remain elusive. Using transcription factor nuclear factor, interleukin 3 regulated (Nfil3) reporter mice and single-cell RNA-sequencing (scRNA-seq), we identified two precursor stages of interleukin 33 (IL-33) receptor ST2-expressing nonlymphoid tissue Treg cells, which resided in the spleen and lymph nodes. Global chromatin profiling of nonlymphoid tissue Treg cells and the two precursor stages revealed a stepwise acquisition of chromatin accessibility and reprogramming toward the nonlymphoid-tissue Treg cell phenotype. Mechanistically, we identified and validated the transcription factor Batf as the driver of the molecular tissue program in the precursors. Understanding this tissue development program will help to harness regenerative properties of tissue Treg cells for therapy.
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000153096 7001_ $$0P:(DE-HGF)0$$aImbusch, Charles D$$b1$$eFirst author
000153096 7001_ $$0P:(DE-He78)2f34b89d62d5e5c651aa1e683844b092$$aHotz-Wagenblatt, Agnes$$b2
000153096 7001_ $$0P:(DE-He78)697cb039ca08f3b7e5a2a52dbf020b46$$aMallm, Jan-Philipp$$b3
000153096 7001_ $$0P:(DE-He78)5b10e57ed1df98e2fd31edbdeed985ba$$aBauer, Katharina$$b4
000153096 7001_ $$0P:(DE-He78)de4915d76b207d077967848783f8d2ba$$aSimon, Malte$$b5
000153096 7001_ $$aRiegel, Dania$$b6
000153096 7001_ $$aRendeiro, André F$$b7
000153096 7001_ $$aBittner, Sebastian$$b8
000153096 7001_ $$aSanderink, Lieke$$b9
000153096 7001_ $$aPant, Asmita$$b10
000153096 7001_ $$aSchmidleithner, Lisa$$b11
000153096 7001_ $$0P:(DE-He78)48a0f3d6278cc8d51ce937ca7db9dba8$$aBraband, Kathrin$$b12
000153096 7001_ $$aEchtenachter, Bernd$$b13
000153096 7001_ $$aFischer, Alexander$$b14
000153096 7001_ $$0P:(DE-He78)ff7fd4eeff966cbac2c2fa199a58e64f$$aGiunchiglia, Valentina$$b15
000153096 7001_ $$aHoffmann, Petra$$b16
000153096 7001_ $$aEdinger, Matthias$$b17
000153096 7001_ $$aBock, Christoph$$b18
000153096 7001_ $$aRehli, Michael$$b19
000153096 7001_ $$0P:(DE-He78)fc949170377b58098e46141d95c72661$$aBrors, Benedikt$$b20
000153096 7001_ $$aSchmidl, Christian$$b21
000153096 7001_ $$0P:(DE-He78)f0638edf1d3f61c0d7ebb587f511733f$$aFeuerer, Markus$$b22$$eLast author
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